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MRC WIMM Centre for Computational Biology

Using computational biology to help understand complex biological systems and combat diseases, from blood disorders to cancer and diabetes.

Kevin Rue-Albrecht receives Software Sustainability Institute Fellowship

Congratulations to Dr Kevin Rue-Albrecht, who has been awarded a Fellowship to improve accessibility and reusability of research software.

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A skeleton model wearing a conference t-shirt.

Unravelling T-Cell Recognition: Insights from Immunology and AI

From 29 September to 1 October 2025, researchers from across the world gathered in Oxford for a unique conference and hackathon exploring how advances in artificial intelligence can deepen understanding of T-cell biology.

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Training

The MRC WIMM Centre for Computational Biology offers training courses in basic data science skills and computational biology methods.

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Illustration of man holding stomach in pain.

© RomarioIen/Shutterstock.com

Study identifies key immune structures in the gut that may drive coeliac disease

Researchers in Oxford have found structures of immune cells in the gut that may be driving the response to gluten in people with coeliac disease and could provide a target for future therapies.

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Wellcome Career Development Award For Agne Antanaviciute

Dr Agne Antanaviciute has won a Wellcome Career Development Award for her research investigating early-life immunity.

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Tools

We aim to share our outputs with the scientific community and have developed a range of open source tools.

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For information about the CCB High Performance Computing Facility see here:

CCB High Performance Computing Facility

Latest publications

Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions.
Journal article

Li H. et al, (2025), Cell
Enhancer heterogeneity in acute lymphoblastic leukemia drives differential gene expression in patients.
Journal article

Smith A. et al, (2025), Blood
CREST-GV: Cell types Ranking and Enrichment Score for selecTive Genetic Variants
Preprint

Riva SG. et al, (2025)
Detecting and quantifying clonal selection in somatic stem cells.
Journal article

Körber V. et al, (2025), Nat Genet

News

Kevin Rue-Albrecht receives Software Sustainability Institute Fellowship

12 December 2025

Colourful spatial transcriptomics images of gut cross-sections in the shape of baubles, arranged to look like a Christmas tree.

It's beginning to look a lot like Gutmas!

28 November 2025

Oxford scientists map the cells that drive Crohn’s disease fistulas

12 November 2025

Detailed map of the genome 1 pixel per nucleotide

Oxford scientists capture genome’s structure in unprecedented detail

5 November 2025

A skeleton model wearing a conference t-shirt.

Unravelling T-Cell Recognition: Insights from Immunology and AI

13 October 2025

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