MRC WIMM Centre for Computational Biology
Using computational biology to help understand complex biological systems and combat diseases, from blood disorders to cancer and diabetes.
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GARFIELD classifies disease-relevant genomic features through integration of functional annotations with association signals.
Iotchkova V. et al, (2019), Nat Genet
Karamitros D. et al, (2018), Nat Immunol, 19, 85 - 97
Sasquatch: predicting the impact of regulatory SNPs on transcription factor binding from cell- and tissue-specific DNase footprints.
Schwessinger R. et al, (2017), Genome Res, 27, 1730 - 1742
Sahakyan AB. et al, (2017), Sci Rep, 7
Platt JL. et al, EMBO Rep, 17, 1410 - 1421