MRC WIMM Centre for Computational Biology
Using computational biology to help understand complex biological systems and combat diseases, from blood disorders to cancer and diabetes.
For information about the CCB High Performance Computing Facility see here:
Study identifies key immune structures in the gut that may drive coeliac disease
Researchers in Oxford have found structures of immune cells in the gut that may be driving the response to gluten in people with coeliac disease and could provide a target for future therapies.
Read moreLatest publications
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Chromothripsis-associated chromosome 21 amplification orchestrates transformation to blast-phase MPN through targetable overexpression of DYRK1A
Journal article
Brierley CK. et al, (2025), Nature Genetics
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Context-specific regulatory genetic variation in MTOR dampens neutrophil-T cell crosstalk in sepsis, modulating disease
Preprint
Zhang P. et al, (2025)
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Immune-epithelial-stromal networks define the cellular ecosystem of the small intestine in celiac disease.
Journal article
FitzPatrick MEB. et al, (2025), Nat Immunol
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Human Enteric Glia Diversity in Health and Disease: New Avenues for the Treatment of Hirschsprung Disease.
Journal article
Windster JD. et al, (2024), Gastroenterology
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Focal deletions of a promoter tether activate the IRX3 oncogene in T-cell acute lymphoblastic leukemia.
Journal article
Rahman S. et al, (2024), Blood
News
MRC WIMM researchers win 2024 RDM Graduate Prize
28 January 2025
The Oxford Omics Data Camp 2024: Spatial Transcriptomics
24 September 2024