Research groups
Websites
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MRC Human Immunology Unit
Research Unit
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MRC Weatherall Institute of Molecular Medicine
Research Institute
Jan Rehwinkel
PhD
Professor of Innate Immunology
Nucleic acid sensing by innate immune receptors
Jan is interested in the molecular mechanisms underlying host-pathogen interactions. In particular, Jan studies how cells detect virus infection. His work lies at the intersection of immunology, virology and molecular biology. After undergraduate training in biology at the University of Heidelberg, Germany, Jan joined the European Molecular Biology Laboratory (EMBL) as a PhD student. Under supervision of Elisa Izaurralde, Jan studied post-transcriptional control of messenger RNA, including the mechanisms by which microRNAs repress their targets, and obtained a PhD in 2007. This background in RNA biology led Jan to develop an interest in nucleic acids in innate immunity. As a postdoctoral fellow, he joined the group of Caetano Reis e Sousa, then at the Cancer Research UK London Research Institute (London, UK). Jan investigated how RNA viruses such as influenza A virus are recognised by innate immune sensors, particularly RIG-I. In 2012, Jan moved to the University of Oxford, UK, to establish his independent research group. His laboratory is part of the MRC Human Immunology Unit and the MRC Weatherall Institute of Molecular Medicine. Jan's research dissects nucleic acid sensing by innate receptors in the context of virus infection, autoinflammatory disease and cancer. Jan's work is funded by the MRC, Wellcome Trust, Lister Institute and European Union.
Key publications
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SAMHD1 Limits the Efficacy of Forodesine in Leukemia by Protecting Cells against the Cytotoxicity of dGTP.
Journal article
Davenne T. et al, (2020), Cell Rep, 31
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Sensing of viral and endogenous RNA by ZBP1/DAI induces necroptosis.
Journal article
Maelfait J. et al, (2017), EMBO J, 36, 2529 - 2543
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Restriction by SAMHD1 Limits cGAS/STING-Dependent Innate and Adaptive Immune Responses to HIV-1.
Journal article
Maelfait J. et al, (2016), Cell Rep, 16, 1492 - 1501
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Viruses transfer the antiviral second messenger cGAMP between cells.
Journal article
Bridgeman A. et al, (2015), Science, 349, 1228 - 1232
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RIG-I detects viral genomic RNA during negative-strand RNA virus infection.
Journal article
Rehwinkel J. et al, (2010), Cell, 140, 397 - 408
Recent publications
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ADAR1: from basic mechanisms to inhibitors.
Journal article
Rehwinkel J. and Mehdipour P., (2024), Trends Cell Biol
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Advancements in pathogen immunity and signaling.
Journal article
Gyrd-Hansen M. et al, (2024), Nat Immunol
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HSV-1 employs UL56 to antagonize expression and function of cGAMP channels.
Journal article
Blest HTW. et al, (2024), Cell Rep, 43
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ZBP1 activation triggers hematopoietic stem and progenitor cell death resulting in bone marrow failure in mice.
Journal article
Roderick-Richardson JE. et al, (2024), Proc Natl Acad Sci U S A, 121
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PARP14 is a PARP with both ADP-ribosyl transferase and hydrolase activities.
Journal article
Đukić N. et al, (2023), Sci Adv, 9
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The Z-nucleic acid sensor ZBP1 in health and disease.
Journal article
Maelfait J. and Rehwinkel J., (2023), J Exp Med, 220
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Low expression of EXOSC2 protects against clinical COVID-19 and impedes SARS-CoV-2 replication.
Journal article
Moll T. et al, (2023), Life Sci Alliance, 6
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Single-cell analysis of signalling and transcriptional responses to type I interferons
Preprint
Rigby R. et al, (2023)
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A simple transwell-based infection system for obtaining pure populations of VZV-infected cells.
Journal article
Hertzog J. and Rehwinkel J., (2022), J Virol Methods
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Human ZBP1 induces cell death-independent inflammatory signaling via RIPK3 and RIPK1.
Journal article
Peng R. et al, (2022), EMBO Rep