Recent publications published by researchers at the MRC WIMM.
Nucleotide metabolic rewiring enables NLRP3 inflammasome hyperactivation in obesity.
Liu D. et al, (2026), Science, 391
ADAR1: from basic mechanisms to inhibitors.
Rehwinkel J. and Mehdipour P., (2025), Trends Cell Biol, 35, 59 - 73
Advancements in pathogen immunity and signaling.
Gyrd-Hansen M. et al, (2024), Nat Immunol, 25, 1322 - 1325
HSV-1 employs UL56 to antagonize expression and function of cGAMP channels.
Blest HTW. et al, (2024), Cell Rep, 43
ZBP1 activation triggers hematopoietic stem and progenitor cell death resulting in bone marrow failure in mice.
Roderick-Richardson JE. et al, (2024), Proc Natl Acad Sci U S A, 121
PARP14 is a PARP with both ADP-ribosyl transferase and hydrolase activities.
Đukić N. et al, (2023), Sci Adv, 9
The Z-nucleic acid sensor ZBP1 in health and disease.
Maelfait J. and Rehwinkel J., (2023), J Exp Med, 220
A simple transwell-based infection system for obtaining pure populations of VZV-infected cells.
Hertzog J. and Rehwinkel J., (2023), J Virol Methods, 312
Low expression of EXOSC2 protects against clinical COVID-19 and impedes SARS-CoV-2 replication.
Moll T. et al, (2023), Life Sci Alliance, 6
Single-cell analysis of signalling and transcriptional responses to type I interferons
Rigby R. et al, (2023)
Human ZBP1 induces cell death-independent inflammatory signaling via RIPK3 and RIPK1.
Peng R. et al, (2022), EMBO Rep, 23
Varicella-Zoster virus ORF9 is an antagonist of the DNA sensor cGAS.
Hertzog J. et al, (2022), EMBO J, 41
The interferon-inducible GTPase MxB promotes capsid disassembly and genome release of herpesviruses.
Serrero MC. et al, (2022), Elife, 11
Low expression of EXOSC2 protects against clinical COVID-19 and impedes SARS-CoV-2 replication.
Moll T. et al, (2022), bioRxiv
Publisher Correction: Chemotherapy-induced transposable elements activate MDA5 to enhance haematopoietic regeneration.
Clapes T. et al, (2021), Nat Cell Biol, 23
Interferon induction held captive in tumor cells.
Bridgeman A. and Rehwinkel J., (2021), Mol Cell, 81, 4109 - 4110
Adenosine-to-inosine editing of endogenous Z-form RNA by the deaminase ADAR1 prevents spontaneous MAVS-dependent type I interferon responses.
Tang Q. et al, (2021), Immunity, 54, 1961 - 1975.e5
Inclusion of cGAMP within virus-like particle vaccines enhances their immunogenicity.
Chauveau L. et al, (2021), EMBO Rep, 22
Fractional response analysis reveals logarithmic cytokine responses in cellular populations.
Nienałtowski K. et al, (2021), Nat Commun, 12
Chemotherapy-induced transposable elements activate MDA5 to enhance haematopoietic regeneration.
Clapes T. et al, (2021), Nat Cell Biol, 23, 704 - 717