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Study reveals blood stem cells can ‘remember’ inflammation

Researchers have discovered that some human blood stem cells retain a lasting “memory” of inflammation, a finding that could help explain links between ageing, chronic disease, and blood cancers

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Banner image featuring the words a leader in translating research from bench to clinic, next to an image of a scientist pipetting a pink liquid.

Translating Our Research

Leading research with the aim of improving human health. World-leading research from scientists at the MRC WIMM has been developed into commercial ventures to translate our discoveries into clinics and benefit patients.

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Academy of Medical Sciences elects Professor Tao Dong as new Fellow

Congratulations to Tao Dong, who has been elected a Fellow of the Academy of Medical Sciences in recognition of her outstanding contributions to advancing medical science through discovery research, translational studies, and the application of scientific knowledge for patient and public benefit.

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Research at the MRC WIMM spans 5 core areas.

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MRC WIMM Research Areas

Research at the MRC WIMM spans 5 core areas.

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Researcher hanlding patient samples in a lab.

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Reversing T cell exhaustion improves effectiveness of myeloma immunotherapies

Researchers at the Icahn School of Medicine at Mount Sinai, Bristol Myers Squibb (BMS), and the University of Oxford have discovered a way to give worn-out immune cells a second wind in the fight against multiple myeloma.

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The MRC WIMM's core mission is to improve human health through the pursuit of fundamental research, the development of new technology, and the translation of discoveries to the clinic.

Discover. Translate. Advance.

The MRC WIMM's core mission is to improve human health through the pursuit of fundamental research, the development of new technology, and the translation of discoveries to the clinic.

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MRC Translational Immune Discovery Unit

Pioneering the future in the study of human immunity to uncover the molecular pathways driving immune-mediated diseases.

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MRC Molecular Haematology Unit

Understanding how mature blood cells are normally made from stem cells and how this is perturbed in common blood disorders.

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Centre for Computational Biology

Using computational biology to help understand complex biological systems and combat a range of human diseases.

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Latest publications

TiO2 Alternative Coatings for Ferric Pyrophosphate Premixes: Stability and Bioaccessibility Relative to Ferrous Fumarate

Teichman DL. et al, (2026), Innovative Food Science and Emerging Technologies, 111

The fetal specific gene LIN28B is essential for human fetal B-lymphopoiesis and initiation of KMT2A::AFF1 infant leukemia.

Ling RE. et al, (2026), Blood

Human haematopoietic stem cells remember inflammatory stress.

Zeng AGX. et al, (2026), Nature

Loop extrusion by cohesin plays a role in enhancer-activated gene expression early in differentiation.

Stolper RJ. et al, (2026), Nat Commun

Initial leukemic epigenomic state determines hypomethylating agent response.

Gopal A. et al, (2026), Nat Commun

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Upcoming Seminars

Scalable Tools to Map T Cell Recognition

Monday, 01 June 2026, 3pm to 4pm

Speaker(s): Dr Stephanie Gaglione (Gladstone Institute)

Series: Unravelling T Cell Recognition: Insights from Immunology and AI

Methylation states underlying clonal fitness at single cell resolution

Tuesday, 02 June 2026, 1pm to 2pm

Speaker(s): Alba Rodriguez Meira, PhD

Series: Molecular Haematology Unit, WIMM

Extrachromosomal DNA (ecDNA): Cancer's Dynamic Circular Genome

Wednesday, 03 June 2026, 12pm to 1pm

Speaker(s): Professor Paul Salomon Mischel (Stanford University)

Series: Molecular Haematology Unit, WIMM

Gene Transfer and Genome Editing of T cells for Cancer Immunotherapy

Thursday, 04 June 2026, 12pm to 1pm

Speaker(s): Professor Chiara Bonini

Series: WIMM THURSDAY SEMINARS

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