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Publications

Recent publications published by researchers at the MRC WIMM.

Group A Streptococcus induces CD1a-autoreactive T cells and promotes psoriatic inflammation.

Chen Y-L. et al, (2023), Sci Immunol, 8

Glycogen synthase 1 targeting reveals a metabolic vulnerability in triple-negative breast cancer.

de Heer EC. et al, (2023), J Exp Clin Cancer Res, 42

Fine-tuning germline mutation rates across evolution.

Bush SJ. and Goriely A., (2023), Trends Genet

A histone deacetylase 3 and mitochondrial complex I axis regulates toxic formaldehyde production.

Wit N. et al, (2023), Sci Adv, 9

Acid-adapted cancer cells alkalinize their cytoplasm by degrading the acid-loading membrane transporter Anion Exchanger 2 (SLC4A2)

MICHL J. et al, (2023), Cell Reports

Specific Modulation of CRISPR Transcriptional Activators through RNA-Sensing Guide RNAs in Mammalian Cells and Zebrafish Embryos

Pelea O. et al, (2023)

Pathogenic variants in the paired-related homeobox 1 gene (PRRX1) cause craniosynostosis with incomplete penetrance.

Tooze RS. et al, (2023), Genet Med

GTAC enables parallel genotyping of multiple genomic loci with chromatin accessibility profiling in single cells.

Turkalj S. et al, (2023), Cell Stem Cell, 30, 722 - 740.e11

ROptimus: a parallel general-purpose adaptive optimisation engine.

Johnson NAG. et al, (2023), Bioinformatics

Age‐related telomere attrition in the human putamen

Schreglmann SR. et al, (2023), Aging Cell

Effect of a 12-week high-intensity exercise intervention: a comparison of cardiac exercise adaptations during biological disease-modifying antirheumatic drug treatment (TNF inhibitors vs IL-6 signalling inhibitors) in patients with rheumatoid arthritis - study protocol for a randomised controlled trial.

Jønck S. et al, (2023), BMJ open, 13

Epigenetic programming defines haematopoietic stem cell fate restriction.

Meng Y. et al, (2023), Nat Cell Biol

Ruxolitinib Versus Best Available Therapy for Polycythemia Vera Intolerant or Resistant to Hydroxycarbamide in a Randomized Trial.

Harrison CN. et al, (2023), J Clin Oncol

The Newfoundland and Labrador mosaic founder population descends from an Irish and British diaspora from 300 years ago.

Gilbert E. et al, (2023), Commun Biol, 6

A phase Ib/II study of ivosidenib with venetoclax +/- azacitidine in IDH1-mutated myeloid malignancies.

Lachowiez CA. et al, (2023), Blood Cancer Discov

Development of Erf-Mediated Craniosynostosis and Pharmacological Amelioration.

Vogiatzi A. et al, (2023), Int J Mol Sci, 24

Evaluation of T cell responses to naturally processed variant SARS-CoV-2 spike antigens in individuals following infection or vaccination.

Yin Z. et al, (2023), Cell Rep, 42

Antibody and memory B cell responses to the dengue virus NS1 antigen in individuals with varying severity of past infection.

Ramu ST. et al, (2023), Immunology

Direct correction of haemoglobin E β-thalassaemia using base editors.

Badat M. et al, (2023), Nat Commun, 14

Elevated Antibody Titers to Epstein-Barr Virus and Cytomegalovirus in Patients with Drug-Induced Lupus.

Knudsen J. et al, (2023), Viruses, 15

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