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Publications

Recent publications published by researchers at the MRC WIMM.

Immunodominance complexity: lessons yet to be learned from dominant T cell responses to SARS-COV-2

Wellington D. et al, (2021), Current Opinion in Virology, 50, 183 - 191

Downregulation of WT1 transcription factor gene expression is required to promote myocardial fate

DA COSTA SIMOES A., (2021), bioRxiv

Adenosine-to-inosine editing of endogenous Z-form RNA by the deaminase ADAR1 prevents spontaneous MAVS-dependent type I interferon responses.

Tang Q. et al, (2021), Immunity, 54, 1961 - 1975.e5

Diminished or inversed dose-rate effect on clonogenic ability in Ku-deficient rodent cells

Tsuchiya H. et al, (2021), Journal of Radiation Research

Functional analysis of XRCC4 mutations in reported microcephaly and growth defect patients in terms of radiosensitivity

Asa AD. et al, (2021), Journal of Radiation Research

Linker region is required for efficient nuclear localization of polynucleotide kinase phosphatase

Tsukada K. et al, (2021), PLoS One

Reprogramming and differentiation-dependent transcriptional alteration of DNA damage response and apoptosis genes in human induced pluripotent stem cells

Shimada M. et al, (2021), Journal of Radiation Research

The FHA domain of PNKP is essential for its recruitment to DNA damage sites and maintenance of genome stability

Tsukada K. et al, (2021), Mutation Research: Fundamental and Molecular Mechanisms of Mutagenesis

Transitions in lineage specification and gene regulatory networks in hematopoietic stem/progenitor cells over human development.

Roy A. et al, (2021), Cell Rep, 36

Single-cell profiling of human bone marrow progenitors reveals mechanisms of failing erythropoiesis in Diamond-Blackfan anemia

Iskander D. et al, (2021), Science Translational Medicine, 13

Combination romidepsin and azacitidine therapy is well tolerated and clinically active in adults with high-risk acute myeloid leukaemia ineligible for intensive chemotherapy.

Loke J. et al, (2021), Br J Haematol

Integrative multi-omics identifies high risk Multiple Myeloma subgroup associated with significant DNA loss and dysregulated DNA repair and cell cycle pathways

Ortiz-Estévez M. et al, (2021)

Polyvinyl alcohol hydrolysis rate and molecular weight influence human and murine HSC activity ex vivo

Sudo K. et al, (2021), Stem Cell Research

Prrx1b restricts fibrosis and promotes Nrg1-dependent cardiomyocyte proliferation during zebrafish heart regeneration

de Bakker DEM. et al, (2021), Development

Distinct patterns of comorbidity prior to diagnosis of incident systemic lupus erythematosus in the Danish population

Hansen RB. et al, (2021), Journal of Autoimmunity, 123

Genomic and evolutionary classification of lung cancer in never smokers

Zhang T. et al, (2021), Nature Genetics, 53, 1348 - 1359

Neuropeptide S receptor 1 is a nonhormonal treatment target in endometriosis.

Tapmeier TT. et al, (2021), Sci Transl Med, 13

Association between circulating CD39+CD8+ T cells pre-chemoradiotherapy and prognosis in patients with nasopharyngeal carcinoma.

Dong D-N. et al, (2021), Chin Med J (Engl)

Distinct tumour antigen-specific T-cell immune response profiles at different hepatocellular carcinoma stages

DONG TAO. et al, (2021), BMC Cancer

The use of genetic tests to diagnose and manage patients with myeloproliferative and myeloproliferative/myelodysplastic neoplasms, and related disorders.

Cross NCP. et al, (2021), British journal of haematology

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