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Publications

Recent publications published by researchers at the MRC WIMM.

A highly accurate platform for clone-specific mutation discovery enables the study of active mutational processes

KaramiNejadRanjbar M. et al, (2020), eLife, 9

H3K79me2/3 controls enhancer-promoter interactions and activation of the pan-cancer stem cell marker PROM1/CD133 in MLL-AF4 leukemia cells.

Godfrey L. et al, (2020), Leukemia

C/EBPalpha and GATA-2 mutations induce bi-lineage acute erythroid leukemia through transformation of a neomorphic neutrophil-erythroid progenitor

NERLOV C. et al, (2020), Cancer Cell

Heterogeneous disease-propagating stem cells in juvenile myelomonocytic leukemia.

Louka E. et al, (2020), BioRix

Single-cell analyses reveal aberrant pathways for megakaryocyte-biased hematopoiesis in myelofibrosis and identify mutant clone-specific targets

ROBERTS I. et al, (2020), Molecular Cell

Whole-genome sequencing of rare disease patients in a national healthcare system

ROBERTS I. and WATKINS H., (2020), Nature

Enhanced immunogenicity of mitochondrial-localized proteins in cancer cells.

Prota G. et al, (2020), Cancer Immunol Res

XPF-ERCC1: Linchpin of DNA crosslink repair

MCHUGH P., (2020), PLoS Genetics

RIG-I-like receptors: their regulation and roles in RNA sensing.

Rehwinkel J. and Gack MU., (2020), Nat Rev Immunol

Myasthenia gravis AChR antibodies inhibit function of rapsyn-clustered AChRs.

Cetin H. et al, (2020), J Neurol Neurosurg Psychiatry

"Enhancing tumour specific immune responses for the treatment of ovarian cancer"

AHMED A. and CERUNDOLO V., (2020), Cancer Immunology Research

Distinct requirements for tissue-resident myeloid lineages during cardiac lymphatic development

JACKSON D. et al, (2020), eLife, Submitted

Enhanced immunogenicity of mitochondrial localised proteins in cancer cells

CERUNDOLO V. et al, (2020), Cancer Immunology Research

Functional Heterogeneity within the Developing Zebrafish Epicardium.

Weinberger M. et al, (2020), Dev Cell, 52, 574 - 590.e6

Ligand-dependent downregulation of MR1 cell surface expression

Awad W. et al, (2020), Proceedings of the National Academy of Sciences of USA

Defective Interferon Gamma Production by Tumor-Specific CD8+ T Cells Is Associated With 5′Methylcytosine-Guanine Hypermethylation of Interferon Gamma Promoter

Abd Hamid M. et al, (2020), Frontiers in Immunology, 11

An integrative view of the regulatory and transcriptional landscapes in mouse hematopoiesis.

Xiang G. et al, (2020), Genome Res

A shared somatic translocation involving CUX1 in monozygotic twins as an early driver of AMKL in Down syndrome.

Bache I. et al, (2020), Blood Cancer J, 10

Re-evaluation of human BDCA-2+ DC during acute sterile skin inflammation.

Chen Y-L. et al, (2020), J Exp Med, 217

Impact of Nanoscale Hindrances on the Relationship between Lipid Packing and Diffusion in Model Membranes.

Beckers D. et al, (2020), J Phys Chem B, 124, 1487 - 1494

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