Recent publications published by researchers at the MRC WIMM.
Group A Streptococcus induces CD1a-autoreactive T cells and promotes psoriatic inflammation.
Journal article
Chen Y-L. et al, (2023), Sci Immunol, 8
Glycogen synthase 1 targeting reveals a metabolic vulnerability in triple-negative breast cancer.
Journal article
de Heer EC. et al, (2023), J Exp Clin Cancer Res, 42
Fine-tuning germline mutation rates across evolution.
Journal article
Bush SJ. and Goriely A., (2023), Trends Genet
A histone deacetylase 3 and mitochondrial complex I axis regulates toxic formaldehyde production.
Journal article
Wit N. et al, (2023), Sci Adv, 9
Acid-adapted cancer cells alkalinize their cytoplasm by degrading the acid-loading membrane transporter Anion Exchanger 2 (SLC4A2)
Journal article
MICHL J. et al, (2023), Cell Reports
Specific Modulation of CRISPR Transcriptional Activators through RNA-Sensing Guide RNAs in Mammalian Cells and Zebrafish Embryos
Preprint
Pelea O. et al, (2023)
Pathogenic variants in the paired-related homeobox 1 gene (PRRX1) cause craniosynostosis with incomplete penetrance.
Journal article
Tooze RS. et al, (2023), Genet Med
GTAC enables parallel genotyping of multiple genomic loci with chromatin accessibility profiling in single cells.
Journal article
Turkalj S. et al, (2023), Cell Stem Cell, 30, 722 - 740.e11
ROptimus: a parallel general-purpose adaptive optimisation engine.
Journal article
Johnson NAG. et al, (2023), Bioinformatics
Age‐related telomere attrition in the human putamen
Journal article
Schreglmann SR. et al, (2023), Aging Cell
Effect of a 12-week high-intensity exercise intervention: a comparison of cardiac exercise adaptations during biological disease-modifying antirheumatic drug treatment (TNF inhibitors vs IL-6 signalling inhibitors) in patients with rheumatoid arthritis - study protocol for a randomised controlled trial.
Journal article
Jønck S. et al, (2023), BMJ open, 13
Epigenetic programming defines haematopoietic stem cell fate restriction.
Journal article
Meng Y. et al, (2023), Nat Cell Biol
Ruxolitinib Versus Best Available Therapy for Polycythemia Vera Intolerant or Resistant to Hydroxycarbamide in a Randomized Trial.
Journal article
Harrison CN. et al, (2023), J Clin Oncol
The Newfoundland and Labrador mosaic founder population descends from an Irish and British diaspora from 300 years ago.
Journal article
Gilbert E. et al, (2023), Commun Biol, 6
A phase Ib/II study of ivosidenib with venetoclax +/- azacitidine in IDH1-mutated myeloid malignancies.
Journal article
Lachowiez CA. et al, (2023), Blood Cancer Discov
Development of Erf-Mediated Craniosynostosis and Pharmacological Amelioration.
Journal article
Vogiatzi A. et al, (2023), Int J Mol Sci, 24
Evaluation of T cell responses to naturally processed variant SARS-CoV-2 spike antigens in individuals following infection or vaccination.
Journal article
Yin Z. et al, (2023), Cell Rep, 42
Antibody and memory B cell responses to the dengue virus NS1 antigen in individuals with varying severity of past infection.
Journal article
Ramu ST. et al, (2023), Immunology
Direct correction of haemoglobin E β-thalassaemia using base editors.
Journal article
Badat M. et al, (2023), Nat Commun, 14
Elevated Antibody Titers to Epstein-Barr Virus and Cytomegalovirus in Patients with Drug-Induced Lupus.
Journal article
Knudsen J. et al, (2023), Viruses, 15