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Publications

Recent publications published by the researchers at the MRC WIMM.

Optimised oligonucleotide substrates to assay XPF ERCC1 nuclease activity for the discovery of DNA repair inhibitors†

MCHUGH PJ. et al, (2019), Chemical Communications

Blood stem cell-forming haemogenic endothelium in zebrafish derives from arterial endothelium.

Bonkhofer F. et al, (2019), Nat Commun, 10

Rationale for targeting BCL6 in MLL-rearranged acute lymphoblastic leukemia.

Hurtz C. et al, (2019), Genes Dev

Development of therapeutic anti-JAGGED1 antibodies for cancer therapy.

Masiero M. et al, (2019), Mol Cancer Ther

A Spontaneous Ring Opening Reaction Leads to a Repair‐Resistant T Oxidation Product in Genomic DNA

Sahakyan A. et al, (2019), ChemBioChem

Discovery of a CD10 negative B-progenitor in human fetal life identifies unique ontogeny-related developmental programs.

O'Byrne S. et al, (2019), Blood

A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A.

Doherty W. et al, (2019), Org Biomol Chem

DeepC: Predicting chromatin interactions using megabase scaled deep neural networks and transfer learning

Schwessinger R. et al, (2019)

Microhomologies are prevalent at Cas9-induced larger deletions.

Owens DDG. et al, (2019), Nucleic acids research, 47, 7402 - 7417

Teasing apart the multiple roles of Shp2 (Ptpn11) in spermatogenesis.

Maher GJ. and Goriely A., (2019), Asian J Androl

A plasmid-encoded peptide from Staphylococcus aureus induces anti-myeloperoxidase nephritogenic autoimmunity.

Ooi JD. et al, (2019), Nat Commun, 10

amplimap: a versatile tool to process and analyze targeted NGS data.

Koelling N. et al, (2019), Bioinformatics

The impact of chemo- and radiotherapy treatments on selfish de novo FGFR2 mutations in sperm of cancer survivors.

Maher GJ. et al, (2019), Hum Reprod

Implementation of a genomic medicine multi-disciplinary team approach for rare disease in the clinical setting: a prospective exome sequencing case series.

Taylor J. et al, (2019), Genome Med, 11

Programmed death-1 receptor (PD-1) and PD-ligand-1 (PD-L1) expression in non-small cell lung cancer and the immune-suppressive effect of anaerobic glycolysis.

Giatromanolaki A. et al, (2019), Med Oncol, 36

Ataxin-3 Links NOD2 and TLR2 Mediated Innate Immune Sensing and Metabolism in Myeloid Cells

Chapman T. et al, (2019), Frontiers in Immunology

BRCA2 abrogation triggers innate immune responses potentiated by treatment with PARP inhibitors.

Reisländer T. et al, (2019), Nature communications, 10

Landscape of transcriptomic interactions between breast cancer and its microenvironment.

Fox NS. et al, (2019), Nature communications, 10

ADGRL4/ELTD1 is a highly conserved angiogenesis-associated orphan adhesion GPCR that emerged with the first vertebrates and comprises 3 evolutionary variants.

Favara DM. et al, (2019), BMC Evol Biol, 19

Mechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome.

Labuhn M. et al, (2019), Cancer Cell

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