MRC WIMM Centre for Computational Biology
Using computational biology to help understand complex biological systems and combat diseases, from blood disorders to cancer and diabetes.
For information about the CCB High Performance Computing Facility see here:
Study identifies key immune structures in the gut that may drive coeliac disease
Researchers in Oxford have found structures of immune cells in the gut that may be driving the response to gluten in people with coeliac disease and could provide a target for future therapies.
Read moreLatest publications
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Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions.
Journal article
Li H. et al, (2025), Cell
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Enhancer heterogeneity in acute lymphoblastic leukemia drives differential gene expression in patients.
Journal article
Smith A. et al, (2025), Blood
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CREST-GV: Cell types Ranking and Enrichment Score for selecTive Genetic Variants
Preprint
Riva SG. et al, (2025)
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Chromothripsis-associated chromosome 21 amplification orchestrates transformation to blast-phase MPN through targetable overexpression of DYRK1A.
Journal article
Brierley CK. et al, (2025), Nat Genet
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REnformer, a single-cell ATAC-seq predicting model to investigate open chromatin sites
Preprint
Riva SG. et al, (2025)
News
Oxford scientists map the cells that drive Crohn’s disease fistulas
12 November 2025
Unravelling T-Cell Recognition: Insights from Immunology and AI
13 October 2025
MRC WIMM researchers receive full Professor title
1 October 2025