The Mead Lab pioneers research into myeloid neoplasms using cutting-edge single-cell genomics and multiomics to uncover novel therapeutic targets. Our ultimate goal is to translate discoveries from the lab through to patient benefit, including interaction with industry and clinical trials. We foster a collaborative and dynamic environment for innovative science, with a focus on career development for members of the team.
About the Mead Lab
Welcome to the Mead Lab, based at the University of Oxford’s Weatherall Institute of Molecular Medicine (WIMM). Our mission is to improve the diagnosis, risk-stratification, and treatment of myeloid malignancies by unraveling the complex interplay of genetic and environmental factors driving disease progression and resistance to therapy. We apply cutting edge techniques at the forefront of single-cell genomics and multiomics, developing innovative experimental approaches to identify novel therapeutic targets and translate discoveries into clinical impact.
Our Vision: To improve patient outcomes in myeloproliferative neoplasms (MPN) and other myeloid blood cancers through cutting-edge science, from fundamental biology to clinical translation.
Research Themes
- Cancer Stem Cell Heterogeneity: Defining the hidden diversity within malignant stem cell compartments in MPN and related malignancies in order to understand how this underlies disease evolution.
- Inflammation and Disease Evolution: Investigating how inflammatory pathways drive clonal selection, therapy resistance and genetic evolution.
- Single-Cell Genomics and Experimental Models: Applying state-of-the-art technologies to dissect tumour ecosystems at unprecedented resolution.
- Clinical Translation: Bridging laboratory discoveries into early-phase and late-phase clinical trials in MPN and myeloid cancers.
Our team
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Adam Mead
Professor of Haematology
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Eleni Louka
Clinician Scientist
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Charlotte Brierley
Academic Clinical Lecturer in Haematology
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Giulia Orlando
Leukaemia UK John Goldman Fellow
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Onima Chowdhury
Clinician Scientist
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Susie Shapiro
Associate Professor of Haematology
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Yuqi Shen
Postdoctoral Researcher
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Rupen Hargreaves
Oxford–BMS Clinical Research Fellow
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Anastasia Kosmidou
DPhil Student
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Richard Salisbury
CRUK Clinical Research Training Fellow
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Amy Wood
DPhil Student
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Charlotte Lees
Clinical research fellow / DPhil student
Why join us?
The Mead Lab offers a dynamic, collaborative and supportive environment for researchers at all career stages. Here’s why you should consider joining us:
- Cutting-Edge Science: Gain hands-on experience with state-of-the-art techniques, including TARGET-seq, single-cell multiomics, spatial transcriptomics, CRISPR screens and in vivo models, positioning you at the forefront of haematology research.
- Mentorship and Career Development: We have a proven track record of mentoring researchers to success with a number of lab alumni receiving prizes for their work and moving on to set up their own independent research groups.
- Collaborative Environment: Work alongside world-class researchers at the WIMM, with collaborations spanning academic groups in Oxford and internationally as well as interaction with industry partners.
- Translational Opportunities: Contribute to projects with direct clinical impact, access to extensive sample collections, including from clinical trials (Professor Mead has been PI/Cl on >60 phase 1-3 trials) and spin-out ventures.
- World-Class Facilities: Access cutting-edge platforms at the WIMM, including single-cell sequencing, spatial transcriptomics, computational biology and transgenic facilities.
Opportunities for Recruits
We are always seeking talented and motivated individuals to join our team, including:
- PhD Students: Join our fully funded DPhil programmes through the University of Oxford, working on high-impact projects with comprehensive training in wet lab and computational techniques.
- Postdoctoral Researchers: Lead innovative projects, develop independent research skills, and benefit from mentorship to secure fellowships or faculty positions.
- Research Technicians: Support cutting-edge experiments, gain technical expertise, and contribute to high-profile publications.
- Clinical Fellows: Engage in translational research bridging bench and bedside, contributing to cutting-edge MPN studies and clinical trials.
Life in Oxford
Based at the WIMM, our lab is part of a vibrant scientific community in Oxford, a historic city offering a rich cultural and academic environment. The WIMM fosters a collegial atmosphere with regular seminars, social events, and career development workshops. Oxford’s global reputation and proximity to world-class collaborators make it an ideal place to advance your research career.
How to Apply
We welcome applications from passionate researchers with a background in haematology, molecular biology, computational biology or related fields. For informal inquiries or to discuss potential projects, feel free to contact Professor Mead directly adam.mead@imm.ox.ac.uk.
Clinical Studies and Trials
Professor Mead’s clinical research is based at the Churchill Hospital in Oxford. He leads the clinical service for patients with myeloproliferative neoplasms (MPN) and chronic myeloid leukaemia (CML) in the Thames Valley and was chair of the National Cancer Research Institute MPN Clinical Studies Subgroup from 2016-2022. This group oversees clinical research in the UK focused on these diseases. Professor Mead is the Principal or Chief Investigator of over 60 clinical trials in CML and MPNs. The Mead Group is the central sample repository for multiple UK MPN trials.
Learn more about MPN clinical research in the UK.