Prof Irene Roberts
|Research Area:||Developmental and Stem Cell Biology|
|Scientific Themes:||Haematology and Developmental Biology & Stem Cells|
My group is interested in the biological basis of the high frequency of haematological disorders which affect newborn infants. In the last 5 years we have specifically focused on the cellular and molecular basis for trisomy 21-mediated perturbation of fetal haematopoiesis and the impact of trisomy 21 on leukaemia initiation. Through immunophenotypic, functional and gene expression studies on isolated primary haematopoietic stem/progenitor cells we have shown that trisomy 21 itself causes abnormal development of haematopoietic progenitors and, more recently, that trisomy 21 interferes with haematopoietic stem cell function, causing a marked megakaryocyte/erythroid bias and profound impairment of B lymphocyte development. We now want to identify the molecular mechanisms which explain how the presence of 3 copies of chromosome 21 produces specific defects in fetal haematopoietic stem/progenitor cells and, ultimately, how this contributes to leukaemogenesis in children with Down syndrome.
|Prof Tassos Karadimitris||Centre for Haematology||Imperial College London||United Kingdom|
|Dr Andi Roy||Centre for Haematology||Imperial College London||United Kingdom|
|Dr Beth Psaila||Centre for Haematology||Imperial College London||United Kingdom|
|Prof Phil Bennett||Institute for Developmental and Reproductive Biology||Imperial College London||United Kingdom|
|Prof Michael Stumpf||Department of Life Sciences||Imperial College London||United Kingdom|
|Dr Jan Henning Klusmann||Department of Paediatric Haematology||University of Hannover||Germany|
|Prof Mitch Weiss||Department of Pediatric Hematology||Children's Hospital of Philadelphia||United States|
|Dr Georg Bohn||Kinderzentrum Linden park AndreasKlinik||Zug||Switzerland|
|Dr Nikos Darzentas||CEITEC MU||Brno||Czech Republic|
|Prof Paresh Vyas MRCP FRCP FRCPath||Nuffield Division of Clinical Laboratory Sciences||Oxford University, Weatherall Institute of Molecular Medicine||United Kingdom|
There are no publications listed for this principal investigator.