Prof Irene Roberts

Research Area: Developmental and Stem Cell Biology
Scientific Themes: Haematology and Developmental Biology & Stem Cells
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Increased fetal megakaryopoiesis in trisomy 21

Increased fetal megakaryopoiesis in trisomy 21

Dyserythropoiesis in neonates with Down syndrome (trisomy 21)

Dyserythropoiesis in neonates with Down syndrome (trisomy 21)

Platelet abnormalities in peripheral blood of neonates with Down syndrome (trisomy 21)

Platelet abnormalities in peripheral blood of neonates with Down syndrome (trisomy 21)

My group is interested in the biological basis of the high frequency of haematological disorders which affect newborn infants. In the last 5 years we have specifically focused on the cellular and molecular basis for trisomy 21-mediated perturbation of fetal haematopoiesis and the impact of trisomy 21 on leukaemia initiation. Through immunophenotypic, functional and gene expression studies on isolated primary haematopoietic stem/progenitor cells we have shown that trisomy 21 itself causes abnormal development of haematopoietic progenitors and, more recently, that trisomy 21 interferes with haematopoietic stem cell function, causing a marked megakaryocyte/erythroid bias and profound impairment of B lymphocyte development. We now want to identify the molecular mechanisms which explain how the presence of 3 copies of chromosome 21 produces specific defects in fetal haematopoietic stem/progenitor cells and, ultimately, how this contributes to leukaemogenesis in children with Down syndrome.

Name Department Institution Country
Prof Tassos Karadimitris Centre for Haematology Imperial College London United Kingdom
Dr Andi Roy Centre for Haematology Imperial College London United Kingdom
Dr Beth Psaila Centre for Haematology Imperial College London United Kingdom
Prof Phil Bennett Institute for Developmental and Reproductive Biology Imperial College London United Kingdom
Prof Michael Stumpf Department of Life Sciences Imperial College London United Kingdom
Dr Jan Henning Klusmann Department of Paediatric Haematology University of Hannover Germany
Prof Mitch Weiss Department of Pediatric Hematology Children's Hospital of Philadelphia United States
Dr Georg Bohn Kinderzentrum Linden park AndreasKlinik Zug Switzerland
Dr Nikos Darzentas CEITEC MU Brno Czech Republic
Prof Paresh Vyas MRCP FRCP FRCPath Nuffield Division of Clinical Laboratory Sciences Oxford University, Weatherall Institute of Molecular Medicine United Kingdom

There are no publications listed for this principal investigator.

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