Recent publications published by researchers at the MRC WIMM.
Unconventional human CD61 pairing with CD103 promotes TCR signaling and antigen-specific T cell cytotoxicity.
Hamid MHBA. et al, (2024), Nat Immunol
A high-throughput two-cell assay for interrogating inhibitory signaling pathways in T cells.
Sharma S. et al, (2024), Life Sci Alliance, 7
CD1 lipidomes reveal lipid-binding motifs and size-based antigen-display mechanisms.
Huang S. et al, (2023), Cell, 186, 4583 - 4596.e13
Group A Streptococcus induces CD1a-autoreactive T cells and promotes psoriatic inflammation.
Chen Y-L. et al, (2023), Sci Immunol, 8
Staphylococcal phosphatidylglycerol antigens activate human T cells via CD1a.
Monnot GC. et al, (2022), Nat Immunol
CD1a promotes systemic manifestations of skin inflammation.
Hardman CS. et al, (2022), Nat Commun, 13
Dengue virus co-opts innate type 2 pathways to escape early control of viral replication.
Fonseka CL. et al, (2022), Commun Biol, 5
A blood atlas of COVID-19 defines hallmarks of disease severity and specificity.
COvid-19 Multi-omics Blood ATlas (COMBAT) Consortium. Electronic address: julian.knight@well.ox.ac.uk None. and COvid-19 Multi-omics Blood ATlas (COMBAT) Consortium None., (2022), Cell, 185, 916 - 938.e58
Phospholipase activity of acyloxyacyl hydrolase induces IL-22-producing CD1a-autoreactive T cells in individuals with psoriasis.
Singh R. et al, (2022), Eur J Immunol, 52, 511 - 524
Evaluation of perturbed iron-homeostasis in a prospective cohort of patients with COVID-19.
Frost JN. et al, (2022), Wellcome open research, 7
Evaluation of perturbed iron-homeostasis in a prospective cohort of patients with COVID-19.
Frost JN. et al, (2022)
Identification of immune correlates of fatal outcomes in critically ill COVID-19 patients.
Youngs J. et al, (2021), PLoS Pathog, 17
Pre-existing asthma as a comorbidity does not modify cytokine responses and severity of COVID-19.
Luo J. et al, (2021), Allergy Asthma Clin Immunol, 17
CD1a selectively captures endogenous cellular lipids that broadly block T cell response.
Cotton RN. et al, (2021), J Exp Med, 218
IL-6 effector function of group 2 innate lymphoid cells (ILC2) is NOD2 dependent.
Hardman CS. et al, (2021), Sci Immunol, 6
A blood atlas of COVID-19 defines hallmarks of disease severity and specificity
COvid-19 Multi-omics Blood ATlas (COMBAT) Consortium None. et al, (2021)
Role of regulatory T cells in psoriasis pathogenesis and treatment.
Nussbaum L. et al, (2021), Br J Dermatol, 184, 14 - 24
Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19.
Peng Y. et al, (2020), Nat Immunol, 21, 1336 - 1345
Re-evaluation of human BDCA-2+ DC during acute sterile skin inflammation.
Chen Y-L. et al, (2020), J Exp Med, 217