Recent publications published by researchers at the MRC WIMM.
Detecting and quantifying clonal selection in somatic stem cells.
Körber V. et al, (2025), Nat Genet
Clonal tracing with somatic epimutations reveals dynamics of blood ageing.
Scherer M. et al, (2025), Nature
Oncogene aberrations drive medulloblastoma progression, not initiation.
Okonechnikov K. et al, (2025), Nature
Multi-omic and single-cell profiling of chromothriptic medulloblastoma reveals genomic and transcriptomic consequences of genome instability.
Smirnov P. et al, (2024), Nat Commun, 15
Neuroblastoma arises in early fetal development and its evolutionary duration predicts outcome
Körber V. et al, (2023), Nature Genetics, 55, 619 - 630
COGNITION: a prospective precision oncology trial for patients with early breast cancer at high risk following neoadjuvant chemotherapy
Pixberg C. et al, (2022), ESMO Open, 7, 100637 - 100637
Carbon ion radiotherapy eradicates medulloblastomas with chromothripsis in an orthotopic Li-Fraumeni patient-derived mouse model
Simovic M. et al, (2021), Neuro-Oncology, 23, 2028 - 2041
Single-cell transcriptomic analyses provide insights into the developmental origins of neuroblastoma
Jansky S. et al, (2021), Nature Genetics, 53, 683 - 693
Inferring growth and genetic evolution of tumors from genome sequences
Körber V. and Höfer T., (2019), Current Opinion in Systems Biology, 16, 1 - 9
Evolutionary Trajectories of IDHWT Glioblastomas Reveal a Common Path of Early Tumorigenesis Instigated Years ahead of Initial Diagnosis
Körber V. et al, (2019), Cancer Cell, 35, 692 - 704.e12