Recent publications published by researchers at the MRC WIMM.
Antibody agonists trigger immune receptor signaling through local exclusion of receptor-type protein tyrosine phosphatases.
Lippert AH. et al, (2024), Immunity, 57, 256 - 270.e10
Single-cell measurements of two-dimensional binding affinity across cell contacts.
Chouliara M. et al, (2021), Biophys J, 120, 5032 - 5040
Trapping or slowing the diffusion of T cell receptors at close contacts initiates T cell signaling.
Chen KY. et al, (2021), Proc Natl Acad Sci U S A, 118
The Costs of Close Contacts: Visualizing the Energy Landscape of Cell Contacts at the Nanoscale.
Kulenkampff K. et al, (2020), Biophys J, 118, 1261 - 1269
A cell topography-based mechanism for ligand discrimination by the T cell receptor.
Fernandes RA. et al, (2019), Proc Natl Acad Sci U S A, 116, 14002 - 14010
Constraints on GPCR Heterodimerization Revealed by the Type-4 Induced-Association BRET Assay.
Felce JH. et al, (2019), Biophys J, 116, 31 - 41
Inside-out mechanisms of CD6 signaling: cytoplasmic and extracellular interactions impact on T cell activation
Santos RF. et al, (2019), EUROPEAN JOURNAL OF IMMUNOLOGY, 49, 346 - 347
Investigation into how T cells trigger on various surfaces
Dam T. et al, (2019), EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 48, S190 - S190
Measuring GPCR Stoichiometry Using Types-1, -2, and -3 Bioluminescence Resonance Energy Transfer-Based Assays.
Felce JH. et al, (2019), Methods Mol Biol, 1947, 183 - 197
Single cell measurements of protein affinity in contacting cells
Chouliara M. et al, (2019), EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 48, S190 - S190
The Interplay of Immune Cell Proteins Affects the Orientation, Organisation and Affinity within a Cell -Cell
Junghans V. et al, (2019), EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 48, S191 - S191
CD45 exclusion- and cross-linking-based receptor signaling together broaden FcεRI reactivity.
Felce JH. et al, (2018), Sci Signal, 11
LAG-3: a very singular immune checkpoint.
Lui Y. and Davis SJ., (2018), Nat Immunol, 19, 1278 - 1279
Reconstitution of immune cell interactions in free-standing membranes.
Jenkins E. et al, (2018), J Cell Sci, 132
Hydrodynamic trapping measures the interaction between membrane-associated molecules.
Junghans V. et al, (2018), Sci Rep, 8
Single-Molecule Light-Sheet Imaging of Suspended T Cells.
Ponjavic A. et al, (2018), Biophys J, 114, 2200 - 2211
Monomeric TCRs drive T cell antigen recognition.
Brameshuber M. et al, (2018), Nat Immunol, 19, 487 - 496
Single-Molecule Analysis of G Protein-Coupled Receptor Stoichiometry: Approaches and Limitations.
Felce JH. et al, (2018), Trends Pharmacol Sci, 39, 96 - 108