Recent publications published by researchers at the MRC WIMM.
Solution structure and synaptic analyses reveal determinants of bispecific T cell engager potency.
Leithner A. et al, (2025), Proc Natl Acad Sci U S A, 122
The Structural Biology of T-Cell Antigen Detection at Close Contacts.
Lui Y. et al, (2025), Immunol Rev, 331
Structure of a fully assembled γδ T cell antigen receptor.
Gully BS. et al, (2024), Nature, 634, 729 - 736
Tracking in situ checkpoint inhibitor-bound target T cells in patients with checkpoint-induced colitis.
Gupta T. et al, (2024), Cancer Cell, 42, 797 - 814.e15
A high-throughput two-cell assay for interrogating inhibitory signaling pathways in T cells.
Sharma S. et al, (2024), Life Sci Alliance, 7
Antibody agonists trigger immune receptor signaling through local exclusion of receptor-type protein tyrosine phosphatases.
Lippert AH. et al, (2024), Immunity, 57, 256 - 270.e10
Tissue-Resident Memory T Cells in Pancreatic Ductal Adenocarcinoma Coexpress PD-1 and TIGIT and Functional Inhibition Is Reversible by Dual Antibody Blockade.
Pearce H. et al, (2023), Cancer Immunol Res, 11, 435 - 449
Antigen discrimination by T cells relies on size-constrained microvillar contact.
Jenkins E. et al, (2023), Nat Commun, 14
The kinase occupancy of T cell coreceptors reconsidered.
Mørch AM. et al, (2022), Proc Natl Acad Sci U S A, 119
Differences in CD80 and CD86 transendocytosis reveal CD86 as a key target for CTLA-4 immune regulation.
Kennedy A. et al, (2022), Nat Immunol, 23, 1365 - 1378
Structure of a fully assembled tumor-specific T cell receptor ligated by pMHC.
Sušac L. et al, (2022), Cell, 185, 3201 - 3213.e19
Single-cell measurements of two-dimensional binding affinity across cell contacts.
Chouliara M. et al, (2021), Biophys J, 120, 5032 - 5040
Trapping or slowing the diffusion of T cell receptors at close contacts initiates T cell signaling.
Chen KY. et al, (2021), Proc Natl Acad Sci U S A, 118
HLA-E-restricted, Gag-specific CD8+ T cells can suppress HIV-1 infection, offering vaccine opportunities.
Yang H. et al, (2021), Sci Immunol, 6
vLUME: 3D virtual reality for single-molecule localization microscopy.
Spark A. et al, (2020), Nat Methods, 17, 1097 - 1099
The Costs of Close Contacts: Visualizing the Energy Landscape of Cell Contacts at the Nanoscale.
Kulenkampff K. et al, (2020), Biophys J, 118, 1261 - 1269
A cell topography-based mechanism for ligand discrimination by the T cell receptor.
Fernandes RA. et al, (2019), Proc Natl Acad Sci U S A, 116, 14002 - 14010
Constraints on GPCR Heterodimerization Revealed by the Type-4 Induced-Association BRET Assay.
Felce JH. et al, (2019), Biophys J, 116, 31 - 41
Inside-out mechanisms of CD6 signaling: cytoplasmic and extracellular interactions impact on T cell activation
Santos RF. et al, (2019), EUROPEAN JOURNAL OF IMMUNOLOGY, 49, 346 - 347