Recent publications published by researchers at the MRC WIMM.
Editing an α-globin enhancer in primary human hematopoietic stem cells as a treatment for β-thalassemia.
Mettananda S. et al, (2017), Nat Commun, 8
Single-cell transcriptomics uncovers distinct molecular signatures of stem cells in chronic myeloid leukemia.
Giustacchini A. et al, (2017), Nat Med, 23, 692 - 702
Subset-Specific Expression of Toll-Like Receptors by Bovine Afferent Lymph Dendritic Cells.
Werling D. et al, (2017), Front Vet Sci, 4
Assessing similarity to primary tissue and cortical layer identity in induced pluripotent stem cell-derived cortical neurons through single-cell transcriptomics.
Handel AE. et al, (2016), Hum Mol Genet, 25, 989 - 1000
Single Cell Whole Transcriptome Analysis Reveals Distinct Molecular Signatures of Therapy-Resistant Chronic Myeloid Leukemia Stem Cells
Giustacchini A. et al, (2015), BLOOD, 126
Migratory sub-populations of afferent lymphatic dendritic cells differ in their interactions with Mycobacterium bovis Bacille Calmette Guerin
Hope JC. et al, (2012), Vaccine, 30, 2357 - 2367
Production and characterization of two monoclonal antibodies to bovine tumour necrosis factor alpha (TNF-alpha) and their cross-reactivity with ovine TNF-alpha.
Kwong LS. et al, (2010), Vet Immunol Immunopathol, 135, 320 - 324
Natural killer cell number and phenotype in bovine peripheral blood is influenced by age.
Graham EM. et al, (2009), Vet Immunol Immunopathol, 132, 101 - 108
A toolbox facilitating stable transfection of Eimeria species.
Clark JD. et al, (2008), Mol Biochem Parasitol, 162, 77 - 86
Development of a simple, sensitive, rapid test which discriminates BCG-vaccinated from Mycobacterium bovis-infected cattle.
Sopp P. et al, (2008), Vaccine, 26, 5470 - 5476
Cross-reactivity of mAbs to human CD antigens with cells from cattle.
Sopp P. et al, (2007), Vet Immunol Immunopathol, 119, 106 - 114
Workshop cluster 1+ gammadelta T-cell receptor T cells from calves express high levels of interferon-gamma in response to stimulation with interleukin-12 and -18.
Price SJ. et al, (2007), Immunology, 120, 57 - 65
Flow cytometric detection of gamma interferon can effectively discriminate Mycobacterium bovis BCG-vaccinated cattle from M. bovis-infected cattle.
Sopp P. et al, (2006), Clin Vaccine Immunol, 13, 1343 - 1348
Subsets of afferent lymph dendritic cells differ in their capacity to phagocytose Mycobacterium bovis
Hope JC. et al, (2005), IMMUNOLOGY, 116, 21 - 21
Summary of the animal homologue section of HLDA8.
Saalmüller A. et al, (2005), Cell Immunol, 236, 51 - 58
Development of detection methods for ruminant interleukin (IL)-4.
Hope JC. et al, (2005), J Immunol Methods, 301, 114 - 123
The role of dendritic cells in shaping the immune response.
Howard CJ. et al, (2004), Anim Health Res Rev, 5, 191 - 195
Phenotypic and functional characterization of intraepithelial lymphocytes in a bovine ligated intestinal loop model of enterohaemorrhagic Escherichia coli infection.
Menge C. et al, (2004), J Med Microbiol, 53, 573 - 579
Exposure to Mycobacterium avium primes the immune system of calves for vaccination with Mycobacterium bovis BCG.
Howard CJ. et al, (2002), Clin Exp Immunol, 130, 190 - 195
Development of detection methods for ruminant interleukin (IL)-12.
Hope JC. et al, (2002), J Immunol Methods, 266, 117 - 126