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Publications

Recent publications published by researchers at the MRC WIMM.

Analysis of sub-kilobase chromatin topology reveals nano-scale regulatory interactions with variable dependence on cohesin and CTCF

Aljahani A. et al, (2021)

Defining genome architecture at base-pair resolution

Hua P. et al, (2021), Nature

Enhancers predominantly regulate gene expression during differentiation via transcription initiation.

Larke MSC. et al, (2021), Mol Cell, 81, 983 - 997.e7

High-resolution targeted 3C interrogation of cis-regulatory element organization at genome-wide scale.

Downes DJ. et al, (2021), Nat Commun, 12

The relationship between genome structure and function.

Oudelaar AM. and Higgs DR., (2020), Nat Rev Genet

The mouse alpha-globin cluster: a paradigm for studying genome regulation and organization.

Oudelaar AM. et al, (2020), Curr Opin Genet Dev, 67, 18 - 24

DeepC: predicting 3D genome folding using megabase-scale transfer learning.

Schwessinger R. et al, (2020), Nat Methods, 17, 1118 - 1124

Dynamics of the 4D genome during in vivo lineage specification and differentiation.

Oudelaar AM. et al, (2020), Nat Commun, 11

Targeted high-resolution chromosome conformation capture at genome-wide scale

Downes DJ. et al, (2020)

A Dynamic Folded Hairpin Conformation Is Associated with α-Globin Activation in Erythroid Cells.

Chiariello AM. et al, (2020), Cell Rep, 30, 2125 - 2135.e5

CaptureCompendium: a comprehensive toolkit for 3C analysis

Telenius J. et al, (2020)

A revised model for promoter competition based on multi-way chromatin interactions at the α-globin locus.

Oudelaar AM. et al, (2019), Nat Commun, 10

An integrated platform to systematically identify causal variants and genes for polygenic human traits

Downes D. et al, (2019)

Dynamics of the 4D genome during lineage specification, differentiation and maturation in vivo

Oudelaar M. et al, (2019)

DOT1L inhibition reveals a distinct subset of enhancers dependent on H3K79 methylation.

Godfrey L. et al, (2019), Nat Commun, 10

Single-allele chromatin interactions identify regulatory hubs in dynamic compartmentalized domains.

Oudelaar AM. et al, (2018), Nat Genet, 50, 1744 - 1751

A tissue-specific self-interacting chromatin domain forms independently of enhancer-promoter interactions.

Brown JM. et al, (2018), Nat Commun, 9

Robust detection of chromosomal interactions from small numbers of cells using low-input Capture-C.

Oudelaar AM. et al, (2017), Nucleic Acids Res, 45

Low-input Capture-C: A Chromosome Conformation Capture Assay to Analyze Chromatin Architecture in Small Numbers of Cells.

Oudelaar AM. et al, (2017), Bio Protoc, 7

Between form and function: the complexity of genome folding.

Oudelaar AM. et al, (2017), Hum Mol Genet, 26, R208 - R215

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