Recent publications published by researchers at the MRC WIMM.
Enhancers predominantly regulate gene expression during differentiation via transcription initiation.
Journal article
Larke MSC. et al, (2021), Mol Cell
High-resolution targeted 3C interrogation of cis-regulatory element organization at genome-wide scale.
Journal article
Downes DJ. et al, (2021), Nat Commun, 12
The relationship between genome structure and function.
Journal article
Oudelaar AM. and Higgs DR., (2020), Nat Rev Genet
The mouse alpha-globin cluster: a paradigm for studying genome regulation and organization.
Journal article
Oudelaar AM. et al, (2020), Curr Opin Genet Dev, 67, 18 - 24
DeepC: predicting 3D genome folding using megabase-scale transfer learning.
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Schwessinger R. et al, (2020), Nat Methods, 17, 1118 - 1124
Dynamics of the 4D genome during in vivo lineage specification and differentiation.
Journal article
Oudelaar AM. et al, (2020), Nat Commun, 11
A Dynamic Folded Hairpin Conformation Is Associated with α-Globin Activation in Erythroid Cells.
Journal article
Chiariello AM. et al, (2020), Cell Rep, 30, 2125 - 2135.e5
CaptureCompendium: a comprehensive toolkit for 3C analysis
Journal article
Telenius J. et al, (2020)
A revised model for promoter competition based on multi-way chromatin interactions at the α-globin locus.
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Oudelaar AM. et al, (2019), Nat Commun, 10
An integrated platform to systematically identify causal variants and genes for polygenic human traits
Journal article
Downes D. et al, (2019)
Dynamics of the 4D genome during lineage specification, differentiation and maturation in vivo
Journal article
Oudelaar M. et al, (2019)
DOT1L inhibition reveals a distinct subset of enhancers dependent on H3K79 methylation.
Journal article
Godfrey L. et al, (2019), Nat Commun, 10
Single-allele chromatin interactions identify regulatory hubs in dynamic compartmentalized domains.
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Oudelaar AM. et al, (2018), Nat Genet, 50, 1744 - 1751
A tissue-specific self-interacting chromatin domain forms independently of enhancer-promoter interactions.
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Brown JM. et al, (2018), Nat Commun, 9
Robust detection of chromosomal interactions from small numbers of cells using low-input Capture-C.
Journal article
Oudelaar AM. et al, (2017), Nucleic Acids Res, 45
Low-input Capture-C: A Chromosome Conformation Capture Assay to Analyze Chromatin Architecture in Small Numbers of Cells.
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Oudelaar AM. et al, (2017), Bio Protoc, 7
Between form and function: the complexity of genome folding.
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Oudelaar AM. et al, (2017), Hum Mol Genet, 26, R208 - R215
Tissue-specific CTCF-cohesin-mediated chromatin architecture delimits enhancer interactions and function in vivo.
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Hanssen LLP. et al, (2017), Nat Cell Biol, 19, 952 - 961
How best to identify chromosomal interactions: a comparison of approaches.
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Davies JOJ. et al, (2017), Nat Methods, 14, 125 - 134
Genetic dissection of the α-globin super-enhancer in vivo.
Journal article
Hay D. et al, (2016), Nat Genet, 48, 895 - 903