Recent publications published by researchers at the MRC WIMM.
Analysis of sub-kilobase chromatin topology reveals nano-scale regulatory interactions with variable dependence on cohesin and CTCF.
Journal article
Aljahani A. et al, (2022), Nat Commun, 13
Dynamic Runx1 chromatin boundaries affect gene expression in hematopoietic development.
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Owens DDG. et al, (2022), Nat Commun, 13
Capture-C: a modular and flexible approach for high-resolution chromosome conformation capture.
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Downes DJ. et al, (2022), Nat Protoc
Publisher Correction: The relationship between genome structure and function.
Journal article
Oudelaar AM. and Higgs DR., (2021), Nat Rev Genet
Analysis of sub-kilobase chromatin topology reveals nano-scale regulatory interactions with variable dependence on cohesin and CTCF
Journal article
Aljahani A. et al, (2021)
Defining genome architecture at base-pair resolution.
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Hua P. et al, (2021), Nature, 595, 125 - 129
The mouse alpha-globin cluster: a paradigm for studying genome regulation and organization.
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Oudelaar AM. et al, (2021), Curr Opin Genet Dev, 67, 18 - 24
Enhancers predominantly regulate gene expression during differentiation via transcription initiation.
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Larke MSC. et al, (2021), Mol Cell, 81, 983 - 997.e7
High-resolution targeted 3C interrogation of cis-regulatory element organization at genome-wide scale.
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Downes DJ. et al, (2021), Nat Commun, 12
The relationship between genome structure and function.
Journal article
Oudelaar AM. and Higgs DR., (2020), Nat Rev Genet
DeepC: predicting 3D genome folding using megabase-scale transfer learning.
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Schwessinger R. et al, (2020), Nat Methods, 17, 1118 - 1124
Dynamics of the 4D genome during in vivo lineage specification and differentiation.
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Oudelaar AM. et al, (2020), Nat Commun, 11
Targeted high-resolution chromosome conformation capture at genome-wide scale
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Downes DJ. et al, (2020)
A Dynamic Folded Hairpin Conformation Is Associated with α-Globin Activation in Erythroid Cells.
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Chiariello AM. et al, (2020), Cell Rep, 30, 2125 - 2135.e5
CaptureCompendium: a comprehensive toolkit for 3C analysis
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Telenius J. et al, (2020)
A revised model for promoter competition based on multi-way chromatin interactions at the α-globin locus.
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Oudelaar AM. et al, (2019), Nat Commun, 10
An integrated platform to systematically identify causal variants and genes for polygenic human traits
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Downes D. et al, (2019)
Dynamics of the 4D genome during lineage specification, differentiation and maturation in vivo
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Oudelaar M. et al, (2019)
DOT1L inhibition reveals a distinct subset of enhancers dependent on H3K79 methylation.
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Godfrey L. et al, (2019), Nat Commun, 10
Single-allele chromatin interactions identify regulatory hubs in dynamic compartmentalized domains.
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Oudelaar AM. et al, (2018), Nat Genet, 50, 1744 - 1751