Recent publications published by researchers at the MRC WIMM.
RIG-I Plays a Dominant Role in the Induction of Transcriptional Changes in Zika Virus-Infected Cells, which Protect from Virus-Induced Cell Death.
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Schilling M. et al, (2020), Cells, 9
Re-evaluation of human BDCA-2+ DC during acute sterile skin inflammation.
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Chen Y-L. et al, (2020), J Exp Med, 217
Cell-intrinsic depletion of Aml1-ETO-expressing pre-leukemic hematopoietic stem cells by K-Ras activating mutation.
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Di Genua C. et al, (2019), Haematologica, 104, 2215 - 2224
Transcriptomic profiling of the myeloma bone-lining niche reveals BMP signalling inhibition to improve bone disease.
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Gooding S. et al, (2019), Nat Commun, 10
Hypoxia-induced switch in SNAT2/SLC38A2 regulation generates endocrine resistance in breast cancer.
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Morotti M. et al, (2019), Proc Natl Acad Sci U S A, 116, 12452 - 12461
SCL/TAL1 cooperates with Polycomb RYBP-PRC1 to suppress alternative lineages in blood-fated cells.
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Chagraoui H. et al, (2018), Nat Commun, 9
Nuclear IGF1R Interacts with Regulatory Regions of Chromatin to Promote RNA Polymerase II Recruitment and Gene Expression Associated with Advanced Tumor Stage.
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Aleksic T. et al, (2018), Cancer Res, 78, 3497 - 3509
Canonical Notch signaling is dispensable for adult steady-state and stress myelo-erythropoiesis.
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Duarte S. et al, (2018), Blood, 131, 1712 - 1719
Hepcidin is regulated by promoter-associated histone acetylation and HDAC3.
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Pasricha S-R. et al, (2017), Nat Commun, 8
Niche-mediated depletion of the normal hematopoietic stem cell reservoir by Flt3-ITD-induced myeloproliferation.
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Mead AJ. et al, (2017), J Exp Med, 214, 2005 - 2021
Intragenic enhancers act as alternative promoters.
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Kowalczyk MS. et al, (2012), Mol Cell, 45, 447 - 458
Global gene expression analysis of human erythroid progenitors.
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Merryweather-Clarke AT. et al, (2011), Blood, 117, e96 - 108
The role of the polycomb complex in silencing alpha-globin gene expression in nonerythroid cells.
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Garrick D. et al, (2008), Blood, 112, 3889 - 3899
Association between active genes occurs at nuclear speckles and is modulated by chromatin environment.
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Brown JM. et al, (2008), J Cell Biol, 182, 1083 - 1097
The expression profile for the tumour suppressor gene PTEN and associated polymorphic markers.
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Hamilton JA. et al, (2000), Br J Cancer, 82, 1671 - 1676