Recent publications published by researchers at the MRC WIMM.
BLM and BRCA1-BARD1 coordinate complementary mechanisms of joint DNA molecule resolution.
Tsukada K. et al, (2024), Mol Cell, 84, 640 - 658.e10
Mechanism of Bloom syndrome complex assembly required for double Holliday junction dissolution and genome stability.
Hodson C. et al, (2022), Proc Natl Acad Sci U S A, 119
Diminished or inversed dose-rate effect on clonogenic ability in Ku-deficient rodent cells
Tsuchiya H. et al, (2021), Journal of Radiation Research
Functional analysis of XRCC4 mutations in reported microcephaly and growth defect patients in terms of radiosensitivity
Asa AD. et al, (2021), Journal of Radiation Research
Linker region is required for efficient nuclear localization of polynucleotide kinase phosphatase
Tsukada K. et al, (2021), PLoS One
Reprogramming and differentiation-dependent transcriptional alteration of DNA damage response and apoptosis genes in human induced pluripotent stem cells
Shimada M. et al, (2021), Journal of Radiation Research
The FHA domain of PNKP is essential for its recruitment to DNA damage sites and maintenance of genome stability
Tsukada K. et al, (2021), Mutation Research: Fundamental and Molecular Mechanisms of Mutagenesis
The Bloom syndrome complex senses RPA-coated single-stranded DNA to restart stalled replication forks.
Shorrocks A-MK. et al, (2021), Nat Commun, 12