Recent publications published by researchers at the MRC WIMM.
Chromothripsis-associated chromosome 21 amplification orchestrates transformation to blast-phase MPN through targetable overexpression of DYRK1A
Brierley CK. et al, (2025), Nature Genetics
Focal deletions of a promoter tether activate the IRX3 oncogene in T-cell acute lymphoblastic leukemia.
Rahman S. et al, (2024), Blood
The state-of-the-art of N-of-1 therapies and the IRDiRC N-of-1 development roadmap
DAVIES J., (2024), Nature Reviews Drug Discovery
Genotyping of Multiple Genomic Loci with Chromatin Accessibility Profiling in Single Cells Links Clonal Hierarchy with Epigenetic Variation in Acute Myeloid Leukemia
Turkalj S. et al, (2022), BLOOD, 140, 1193 - 1194