Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Publications

Recent publications published by researchers at the MRC WIMM.

Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions.

Li H. et al, (2025), Cell

Enhancer heterogeneity in acute lymphoblastic leukemia drives differential gene expression in patients.

Smith A. et al, (2025), Blood

Chromothripsis-associated chromosome 21 amplification orchestrates transformation to blast-phase MPN through targetable overexpression of DYRK1A.

Brierley CK. et al, (2025), Nat Genet

Ancient genomic linkage of α-globin and Nprl3 couples metabolism with erythropoiesis.

Preston AE. et al, (2025), Nat Commun, 16

Context-specific regulatory genetic variation in MTOR dampens neutrophil-T cell crosstalk in sepsis, modulating disease

Zhang P. et al, (2025)

The state-of-the-art of N-of-1 therapies and the IRDiRC N-of-1 development roadmap.

Jonker AH. et al, (2025), Nat Rev Drug Discov, 24, 40 - 56

Focal deletions of a promoter tether activate the IRX3 oncogene in T-cell acute lymphoblastic leukemia.

Rahman S. et al, (2024), Blood, 144, 2319 - 2326

Single-cell technologies meet Hi-C.

Hughes JR. and Davies JOJ., (2024), Nat Genet, 56, 1542 - 1543

Pioneer activity distinguishes activating from non-activating SOX2 binding sites.

Maresca M. et al, (2023), EMBO J, 42

Author Correction: Capture-C: a modular and flexible approach for high-resolution chromosome conformation capture.

Downes DJ. et al, (2023), Nat Protoc, 18

Ancient genomic linkage couples metabolism with erythroid development.

Preston AE. et al, (2023), bioRxiv

MLL-AF4 cooperates with PAF1 and FACT to drive high-density enhancer interactions in leukemia.

Crump NT. et al, (2023), Nat Commun, 14

Determining chromatin architecture with Micro Capture-C.

Hamley JC. et al, (2023), Nat Protoc, 18, 1687 - 1711

GTAC enables parallel genotyping of multiple genomic loci with chromatin accessibility profiling in single cells.

Turkalj S. et al, (2023), Cell Stem Cell, 30, 722 - 740.e11

Direct correction of haemoglobin E β-thalassaemia using base editors.

Badat M. et al, (2023), Nat Commun, 14

Sustained MYB Activity Is Necessary for Oncogenic Transcription in KMT2A-Rearranged Acute Lymphoblastic Leukemia through Enhancer-Promoter Interactions and Epigenetic Modifications at Enhancers

Lau J. et al, (2023), BLOOD, 142

Whole-genome sequencing of chronic lymphocytic leukemia identifies subgroups with distinct biological and clinical features.

Robbe P. et al, (2022), Nat Genet, 54, 1675 - 1689

Analysis of sub-kilobase chromatin topology reveals nano-scale regulatory interactions with variable dependence on cohesin and CTCF.

Aljahani A. et al, (2022), Nat Commun, 13

Capture-C: a modular and flexible approach for high-resolution chromosome conformation capture.

Downes DJ. et al, (2022), Nat Protoc, 17, 445 - 475

Genotyping of Multiple Genomic Loci with Chromatin Accessibility Profiling in Single Cells Links Clonal Hierarchy with Epigenetic Variation in Acute Myeloid Leukemia

Turkalj S. et al, (2022), BLOOD, 140, 1193 - 1194

Load More

Include forthcoming?