Recent publications published by researchers at the MRC WIMM.
Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions.
Li H. et al, (2025), Cell, 188, 7175 - 7193.e19
Enhancer heterogeneity in acute lymphoblastic leukemia drives differential gene expression in patients.
Smith AL. et al, (2025), Blood, 146, 2073 - 2087
Chromothripsis-associated chromosome 21 amplification orchestrates transformation to blast-phase MPN through targetable overexpression of DYRK1A.
Brierley CK. et al, (2025), Nat Genet, 57, 1478 - 1492
Ancient genomic linkage of α-globin and Nprl3 couples metabolism with erythropoiesis.
Preston AE. et al, (2025), Nat Commun, 16
The state-of-the-art of N-of-1 therapies and the IRDiRC N-of-1 development roadmap.
Jonker AH. et al, (2025), Nat Rev Drug Discov, 24, 40 - 56
Focal deletions of a promoter tether activate the IRX3 oncogene in T-cell acute lymphoblastic leukemia.
Rahman S. et al, (2024), Blood, 144, 2319 - 2326
Pioneer activity distinguishes activating from non-activating SOX2 binding sites.
Maresca M. et al, (2023), EMBO J, 42
Author Correction: Capture-C: a modular and flexible approach for high-resolution chromosome conformation capture.
Downes DJ. et al, (2023), Nat Protoc, 18
Ancient genomic linkage couples metabolism with erythroid development.
Preston AE. et al, (2023), bioRxiv
MLL-AF4 cooperates with PAF1 and FACT to drive high-density enhancer interactions in leukemia.
Crump NT. et al, (2023), Nat Commun, 14
Determining chromatin architecture with Micro Capture-C.
Hamley JC. et al, (2023), Nat Protoc, 18, 1687 - 1711
GTAC enables parallel genotyping of multiple genomic loci with chromatin accessibility profiling in single cells.
Turkalj S. et al, (2023), Cell Stem Cell, 30, 722 - 740.e11
Direct correction of haemoglobin E β-thalassaemia using base editors.
Badat M. et al, (2023), Nat Commun, 14
Whole-genome sequencing of chronic lymphocytic leukemia identifies subgroups with distinct biological and clinical features.
Robbe P. et al, (2022), Nat Genet, 54, 1675 - 1689
Analysis of sub-kilobase chromatin topology reveals nano-scale regulatory interactions with variable dependence on cohesin and CTCF.
Aljahani A. et al, (2022), Nat Commun, 13
Capture-C: a modular and flexible approach for high-resolution chromosome conformation capture.
Downes DJ. et al, (2022), Nat Protoc, 17, 445 - 475
Genotyping of Multiple Genomic Loci with Chromatin Accessibility Profiling in Single Cells Links Clonal Hierarchy with Epigenetic Variation in Acute Myeloid Leukemia
Turkalj S. et al, (2022), BLOOD, 140, 1193 - 1194