Recent publications published by researchers at the MRC WIMM.
Menin maintains enhancer-promoter interactions in a leukemia-specific manner
Sharlandjieva V. et al, (2026)
Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions.
Li H. et al, (2025), Cell, 188, 7175 - 7193.e19
Enhancer heterogeneity in acute lymphoblastic leukemia drives differential gene expression in patients.
Smith AL. et al, (2025), Blood, 146, 2073 - 2087
Chromothripsis-associated chromosome 21 amplification orchestrates transformation to blast-phase MPN through targetable overexpression of DYRK1A.
Brierley CK. et al, (2025), Nat Genet, 57, 1478 - 1492
Ancient genomic linkage of α-globin and Nprl3 couples metabolism with erythropoiesis.
Preston AE. et al, (2025), Nat Commun, 16
The state-of-the-art of N-of-1 therapies and the IRDiRC N-of-1 development roadmap.
Jonker AH. et al, (2025), Nat Rev Drug Discov, 24, 40 - 56
Focal deletions of a promoter tether activate the IRX3 oncogene in T-cell acute lymphoblastic leukemia.
Rahman S. et al, (2024), Blood, 144, 2319 - 2326
Pioneer activity distinguishes activating from non-activating SOX2 binding sites.
Maresca M. et al, (2023), EMBO J, 42
Author Correction: Capture-C: a modular and flexible approach for high-resolution chromosome conformation capture.
Downes DJ. et al, (2023), Nat Protoc, 18
Ancient genomic linkage couples metabolism with erythroid development.
Preston AE. et al, (2023), bioRxiv
MLL-AF4 cooperates with PAF1 and FACT to drive high-density enhancer interactions in leukemia.
Crump NT. et al, (2023), Nat Commun, 14
Determining chromatin architecture with Micro Capture-C.
Hamley JC. et al, (2023), Nat Protoc, 18, 1687 - 1711
GTAC enables parallel genotyping of multiple genomic loci with chromatin accessibility profiling in single cells.
Turkalj S. et al, (2023), Cell Stem Cell, 30, 722 - 740.e11
Direct correction of haemoglobin E β-thalassaemia using base editors.
Badat M. et al, (2023), Nat Commun, 14
Whole-genome sequencing of chronic lymphocytic leukemia identifies subgroups with distinct biological and clinical features.
Robbe P. et al, (2022), Nat Genet, 54, 1675 - 1689
Analysis of sub-kilobase chromatin topology reveals nano-scale regulatory interactions with variable dependence on cohesin and CTCF.
Aljahani A. et al, (2022), Nat Commun, 13
Capture-C: a modular and flexible approach for high-resolution chromosome conformation capture.
Downes DJ. et al, (2022), Nat Protoc, 17, 445 - 475