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Recent publications published by researchers at the MRC WIMM.

Resistance to PARP Inhibitors: Lessons from Preclinical Models of BRCA-Associated Cancer

Journal article

Gogola E. et al, (2019), Annual Review of Cancer Biology, 3, 235 - 254

Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality.

Journal article

Gogola E. et al, (2018), Cancer Cell, 33, 1078 - 1093.e12

BRCA-deficient mouse mammary tumor organoids to study cancer-drug resistance

Journal article

Duarte AA. et al, (2018), Nature Methods, 15, 134 - 140

A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity

Journal article

Sachs N. et al, (2018), Cell, 172, 373 - 386.e10

EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation

Journal article

Rondinelli B. et al, (2017), Nature Cell Biology, 19, 1371 - 1378

TRIM28 Is an Epigenetic Barrier to Induced Pluripotent Stem Cell Reprogramming

Journal article

Miles DC. et al, (2017), STEM CELLS, 35, 147 - 157

Replication fork stability confers chemoresistance in BRCA-deficient cells

Journal article

Ray Chaudhuri A. et al, (2016), Nature, 535, 382 - 387

Selective resistance to the PARP inhibitor olaparib in a mouse model for BRCA1-deficient metaplastic breast cancer

Journal article

Henneman L. et al, (2015), Proceedings of the National Academy of Sciences, 112, 8409 - 8414

REV7 counteracts DNA double-strand break resection and affects PARP inhibition.

Journal article

Xu G. et al, (2015), Nature, 521, 541 - 544