Recent publications published by researchers at the MRC WIMM.
A histone deacetylase 3 and mitochondrial complex I axis regulates toxic formaldehyde production.
Wit N. et al, (2023), Sci Adv, 9
Truncated FGFR2 is a clinically actionable oncogene in multiple cancers.
Zingg D. et al, (2022), Nature, 608, 609 - 617
Loss of nuclear DNA ligase III reverts PARP inhibitor resistance in BRCA1/53BP1 double-deficient cells by exposing ssDNA gaps.
Paes Dias M. et al, (2021), Molecular cell, 81, 4692 - 4708.e9
Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality.
Gogola E. et al, (2019), Cancer Cell, 35, 950 - 952
Resistance to PARP Inhibitors: Lessons from Preclinical Models of BRCA-Associated Cancer
Gogola E. et al, (2019), Annual Review of Cancer Biology, 3, 235 - 254
Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality.
Gogola E. et al, (2018), Cancer Cell, 33, 1078 - 1093.e12
The CST Complex Mediates End Protection at Double-Strand Breaks and Promotes PARP Inhibitor Sensitivity in BRCA1-Deficient Cells.
Barazas M. et al, (2018), Cell Rep, 23, 2107 - 2118
Multifaceted Impact of MicroRNA 493-5p on Genome-Stabilizing Pathways Induces Platinum and PARP Inhibitor Resistance in BRCA2-Mutated Carcinomas
Meghani K. et al, (2018), Cell Reports, 23, 100 - 111
BRCA-deficient mouse mammary tumor organoids to study cancer-drug resistance
Duarte AA. et al, (2018), Nature Methods, 15, 134 - 140
A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity
Sachs N. et al, (2018), Cell, 172, 373 - 386.e10
EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation
Rondinelli B. et al, (2017), Nature Cell Biology, 19, 1371 - 1378
Progression through mitosis promotes PARP inhibitor-induced cytotoxicity in homologous recombination-deficient cancer cells.
Schoonen PM. et al, (2017), Nat Commun, 8
TRIM28 Is an Epigenetic Barrier to Induced Pluripotent Stem Cell Reprogramming
Miles DC. et al, (2017), STEM CELLS, 35, 147 - 157
Replication fork stability confers chemoresistance in BRCA-deficient cells
Ray Chaudhuri A. et al, (2016), Nature, 535, 382 - 387
Selective resistance to the PARP inhibitor olaparib in a mouse model for BRCA1-deficient metaplastic breast cancer
Henneman L. et al, (2015), Proceedings of the National Academy of Sciences, 112, 8409 - 8414
REV7 counteracts DNA double-strand break resection and affects PARP inhibition.
Xu G. et al, (2015), Nature, 521, 541 - 544