Recent publications published by researchers at the MRC WIMM.
Single cell spatial analysis reveals inflammatory foci of immature neutrophil and CD8 T cells in COVID-19 lungs.
Weeratunga P. et al, (2023), Nat Commun, 14
Unbiased single cell spatial analysis localises inflammatory clusters of immature neutrophils-CD8 T cells to alveolar progenitor cells in fatal COVID-19 lungs
COSMIC – COVID-19 Lung Single Cell Mass Cytometry Imaging Consortium STUDY None. et al, (2022)
MicroRNA-570 is a novel regulator of cellular senescence and inflammaging.
Baker JR. et al, (2019), FASEB J, 33, 1605 - 1616
The dynamic shuttling of SIRT1 between cytoplasm and nuclei in bronchial epithelial cells by single and repeated cigarette smoke exposure.
Yanagisawa S. et al, (2018), PLoS One, 13
Quercetin restores corticosteroid sensitivity in cells from patients with chronic obstructive pulmonary disease.
Mitani A. et al, (2017), Exp Lung Res, 43, 417 - 425
DJ-1 and its anti-oxidative stress response regulates the expression of sirtuin-1 in COPD epithelial cells
Koga T. et al, (2017), EUROPEAN RESPIRATORY JOURNAL, 50
RNA-binding protein HuR inhibits the expression of sirtuin-1 in patients with COPD
Baker JR. et al, (2017), EUROPEAN RESPIRATORY JOURNAL, 50
Decreased phosphatase PTEN amplifies PI3K signaling and enhances proinflammatory cytokine release in COPD.
Yanagisawa S. et al, (2017), Am J Physiol Lung Cell Mol Physiol, 313, L230 - L239
Antagomir Of Microrna-34a Rescues Cellular Senescence In Bronchial Epithelial Cells Of COPD Patients
Baker J. et al, (2017), AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 195
Oxidative stress dependent microRNA-34a activation via PI3Kα reduces the expression of sirtuin-1 and sirtuin-6 in epithelial cells.
Baker JR. et al, (2016), Sci Rep, 6
Decreased PTEN amplifies PI3K signaling and enhances pro-inflammatory cytokine release in COPD
Yanagiasawa S. et al, (2016), EUROPEAN RESPIRATORY JOURNAL, 48
Restoration of Corticosteroid Sensitivity in Chronic Obstructive Pulmonary Disease by Inhibition of Mammalian Target of Rapamycin.
Mitani A. et al, (2016), Am J Respir Crit Care Med, 193, 143 - 153
INHIBITION OF MTOR RESTORES CORTICOSTEROID SENSITIVITY IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE
Mitani A. et al, (2015), RESPIROLOGY, 20, 44 - 44
Activation of the mTOR signaling pathway by L-leucine in 5q- syndrome and other RPS14-deficient erythroblasts.
Yip BH. et al, (2013), Leukemia, 27, 1760 - 1763
Activation of the mTOR signaling pathway by L-leucine in 5q-syndrome and other RPS14-deficient erythroblasts
Yip BH. et al, (2013), Leukemia, 27, 1760 - 1763
Activation of the mTOR pathway by the amino acid (L)-leucine in the 5q- syndrome and other ribosomopathies.
Boultwood J. et al, (2013), Adv Biol Regul, 53, 8 - 17
Activation of the mTOR Signaling Pathway by L-Leucine in RPS14-Deficient Erythroid Cells
Yip BH. et al, (2012), BLOOD, 120
Effects of L-leucine in 5q- syndrome and other RPS14-deficient erythroblasts.
Yip BH. et al, (2012), Leukemia, 26, 2154 - 2158