Recent publications published by researchers at the MRC WIMM.
Exploring cellular changes in ruptured human quadriceps tendons at single-cell resolution
Mimpen JY. et al, (2024)
Single nucleus and spatial transcriptomic profiling of healthy human hamstring tendon.
Mimpen JY. et al, (2024), FASEB J, 38
Comprehensive epigenomic profiling reveals the extent of disease-specific chromatin states and informs target discovery in ankylosing spondylitis
Brown AC. et al, (2023), Cell Genomics, 100306 - 100306
Chromosome conformation capture approaches to investigate 3D genome architecture in Ankylosing Spondylitis.
Davidson C. et al, (2023), Front Genet, 14
FUNCTIONAL GENOMICS INVESTIGATION OF THE ANKYLOSING SPONDYLITIS ASSOCIATED LOCUS RUNX3
Cohen C. et al, (2022), ANNALS OF THE RHEUMATIC DISEASES, 81, 231 - 231
Functional Genomic Analysis of a RUNX3 Polymorphism Associated With Ankylosing Spondylitis.
Vecellio M. et al, (2021), Arthritis Rheumatol, 73, 980 - 990
INVESTIGATING THE ANKYLOSING SPONDYLITIS-ASSOCIATED REGULATORY SNPS AT THE RUNX3 LOCUS WITH A FUNCTIONAL GENOMICS APPROACH
Vecellio M. et al, (2021), ANNALS OF THE RHEUMATIC DISEASES, 80, 411 - 411
COMPREHENSIVE EPIGENOMIC PROFILING REVEALS DISEASE-SPECIFIC CHROMATIN STATES IN ANKYLOSING SPONDYLITIS
Cohen CJ. et al, (2021), CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 39, 1155 - 1155
Disruption of c-MYC Binding and Chromosomal Looping Involving Genetic Variants Associated With Ankylosing Spondylitis Upstream of the RUNX3 Promoter.
Cohen CJ. et al, (2021), Front Genet, 12
Perspectives on the Genetic Associations of Ankylosing Spondylitis.
Wordsworth BP. et al, (2021), Front Immunol, 12
The severity of ankylosing spondylitis and responses to anti-tumour necrosis factor biologics are not influenced by the tumour necrosis factor receptor polymorphism incriminated in multiple sclerosis.
Watts L. et al, (2019), Genes Immun, 20, 167 - 171
Quantifying the genetic risk for the development of axial spondyloarthropathy: could this become a diagnostic tool?
Wordsworth BP. et al, (2018), Curr Opin Rheumatol, 30, 319 - 323
INVESTIGATING THE REGULATORY SNPS AT THE RUNX3 LOCUS ASSOCIATED WITH ANKYLOSING SPONDYLITIS
Vecellio ML. et al, (2018), ANNALS OF THE RHEUMATIC DISEASES, 77, 158 - 158
Evidence for a second ankylosing spondylitis-associated RUNX3 regulatory polymorphism.
Vecellio M. et al, (2018), RMD Open, 4
EXPLORING THE ANKYLOSING SPONDYLITIS-ASSOCIATED REGULATORY SNPs AT THE RUNX3 LOCUS
Vecellio M. et al, (2018), CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 36, 734 - 734
RUNX3 and T-Bet in Immunopathogenesis of Ankylosing Spondylitis-Novel Targets for Therapy?
Vecellio M. et al, (2018), Front Immunol, 9
Investigation of a possible extended risk haplotype in the IL23R region associated with ankylosing spondylitis.
Roberts AR. et al, (2017), Genes Immun, 18, 105 - 108
An ankylosing spondylitis-associated genetic variant in the IL23R-IL12RB2 intergenic region modulates enhancer activity and is associated with increased Th1-cell differentiation.
Roberts AR. et al, (2016), Ann Rheum Dis, 75, 2150 - 2156
The genetic association of RUNX3 with ankylosing spondylitis can be explained by allele-specific effects on IRF4 recruitment that alter gene expression.
Vecellio M. et al, (2016), Ann Rheum Dis, 75, 1534 - 1540