Recent publications published by researchers at the MRC WIMM.
HSV-1 employs UL56 to antagonize expression and function of cGAMP channels.
Journal article
Blest HTW. et al, (2024), Cell Rep, 43
Varicella-Zoster virus ORF9 is an antagonist of the DNA sensor cGAS.
Journal article
Hertzog J. et al, (2022), EMBO J, 41
Interferon induction held captive in tumor cells.
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Bridgeman A. and Rehwinkel J., (2021), Mol Cell, 81, 4109 - 4110
Adenosine-to-inosine editing of endogenous Z-form RNA by the deaminase ADAR1 prevents spontaneous MAVS-dependent type I interferon responses.
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Tang Q. et al, (2021), Immunity, 54, 1961 - 1975.e5
Inclusion of cGAMP within virus-like particle vaccines enhances their immunogenicity.
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Chauveau L. et al, (2021), EMBO Rep, 22
Chemotherapy-induced transposable elements activate MDA5 to enhance haematopoietic regeneration.
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Clapes T. et al, (2021), Nat Cell Biol, 23, 704 - 717
The RNA sensor MDA5 detects SARS-CoV-2 infection.
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Sampaio NG. et al, (2021), Sci Rep, 11
RIG-I Plays a Dominant Role in the Induction of Transcriptional Changes in Zika Virus-Infected Cells, which Protect from Virus-Induced Cell Death.
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Schilling M. et al, (2020), Cells, 9
SAMHD1 Limits the Efficacy of Forodesine in Leukemia by Protecting Cells against the Cytotoxicity of dGTP.
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Davenne T. et al, (2020), Cell Rep, 31
Deoxyguanosine is a TLR7 agonist.
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Davenne T. et al, (2020), Eur J Immunol, 50, 56 - 62
Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence.
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Glück S. et al, (2017), Nat Cell Biol, 19, 1061 - 1070
Sensing of viral and endogenous RNA by ZBP1/DAI induces necroptosis.
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Maelfait J. et al, (2017), EMBO J, 36, 2529 - 2543
Purification of Cyclic GMP-AMP from Viruses and Measurement of Its Activity in Cell Culture.
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Mayer A. et al, (2017), Methods Mol Biol, 1656, 143 - 152
Vector delivery-dependant effect of human tissue plasminogen activator signal peptide on vaccine induction of T cells
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Hanke T. et al, (2016), Journal of HIV and AIDS
Restriction by SAMHD1 Limits cGAS/STING-Dependent Innate and Adaptive Immune Responses to HIV-1.
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Maelfait J. et al, (2016), Cell Rep, 16, 1492 - 1501
Viruses transfer the antiviral second messenger cGAMP between cells.
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Bridgeman A. et al, (2015), Science, 349, 1228 - 1232
Transient IL-10 receptor blockade can enhance CD8(+) T cell responses to a simian adenovirus-vectored HIV-1 conserved region immunogen.
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Clutton G. et al, (2015), Hum Vaccin Immunother, 11, 1030 - 1035
Characterization of T-cell responses to conserved regions of the HIV-1 proteome in BALB/c mice.
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Ondondo B. et al, (2014), Clin Vaccine Immunol, 21, 1565 - 1572
Vaccine-elicited human T cells recognizing conserved protein regions inhibit HIV-1.
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Borthwick N. et al, (2014), Mol Ther, 22, 464 - 475