Recent publications published by researchers at the MRC WIMM.
HSV-1 employs UL56 to antagonize expression and function of cGAMP channels.
Blest HTW. et al, (2024), Cell Rep, 43
Varicella-Zoster virus ORF9 is an antagonist of the DNA sensor cGAS.
Hertzog J. et al, (2022), EMBO J, 41
Interferon induction held captive in tumor cells.
Bridgeman A. and Rehwinkel J., (2021), Mol Cell, 81, 4109 - 4110
Adenosine-to-inosine editing of endogenous Z-form RNA by the deaminase ADAR1 prevents spontaneous MAVS-dependent type I interferon responses.
Tang Q. et al, (2021), Immunity, 54, 1961 - 1975.e5
Inclusion of cGAMP within virus-like particle vaccines enhances their immunogenicity.
Chauveau L. et al, (2021), EMBO Rep, 22
Chemotherapy-induced transposable elements activate MDA5 to enhance haematopoietic regeneration.
Clapes T. et al, (2021), Nat Cell Biol, 23, 704 - 717
SAMHD1 Limits the Efficacy of Forodesine in Leukemia by Protecting Cells against the Cytotoxicity of dGTP.
Davenne T. et al, (2020), Cell Rep, 31
Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence.
Glück S. et al, (2017), Nat Cell Biol, 19, 1061 - 1070
Sensing of viral and endogenous RNA by ZBP1/DAI induces necroptosis.
Maelfait J. et al, (2017), EMBO J, 36, 2529 - 2543
Purification of Cyclic GMP-AMP from Viruses and Measurement of Its Activity in Cell Culture.
Mayer A. et al, (2017), Methods Mol Biol, 1656, 143 - 152
Vector delivery-dependant effect of human tissue plasminogen activator signal peptide on vaccine induction of T cells
Hanke T. et al, (2016), Journal of HIV and AIDS
Restriction by SAMHD1 Limits cGAS/STING-Dependent Innate and Adaptive Immune Responses to HIV-1.
Maelfait J. et al, (2016), Cell Rep, 16, 1492 - 1501
Viruses transfer the antiviral second messenger cGAMP between cells.
Bridgeman A. et al, (2015), Science, 349, 1228 - 1232
Transient IL-10 receptor blockade can enhance CD8(+) T cell responses to a simian adenovirus-vectored HIV-1 conserved region immunogen.
Clutton G. et al, (2015), Hum Vaccin Immunother, 11, 1030 - 1035
Characterization of T-cell responses to conserved regions of the HIV-1 proteome in BALB/c mice.
Ondondo B. et al, (2014), Clin Vaccine Immunol, 21, 1565 - 1572
Vaccine-elicited human T cells recognizing conserved protein regions inhibit HIV-1.
Borthwick N. et al, (2014), Mol Ther, 22, 464 - 475