Recent publications published by researchers at the MRC WIMM.
Silencing of SOD1 sensitises ATRX-deficient cells to camptothecin treatment through increased activity of the Alternative Lengthening of Telomeres pathway
ROSE A. et al, (2025), Human Molecular Genetics
Elevated reactive oxygen species can drive the alternative lengthening of telomeres pathway in ATRX-null cancers.
Goncalves T. et al, (2025), Nucleic Acids Res, 53
Phosphorylation of 'SDT-like' motifs in ATRX mediates its interaction with the MRN complex and is important for ALT pathway suppression.
Goncalves T. et al, (2024), Open Biol, 14
Hypoxia-induced transcriptional stress is mediated by ROS-induced R-loops.
Ma TS. et al, (2023), Nucleic Acids Res, 51, 11584 - 11599
Induction of the alternative lengthening of telomeres pathway by trapping of proteins on DNA.
Rose AM. et al, (2023), Nucleic Acids Res, 51, 6509 - 6527
Ethnicity, child health and paediatric services.
Qureshi Z. et al, (2023), Arch Dis Child, 108, 453 - 454
The emergence of Fanconi anaemia type S: a phenotypic spectrum of biallelic BRCA1 mutations.
Hughes T. and Rose AM., (2023), Front Oncol, 13
Risk and Lag-time for Development of Lacrimal Gland Carcinoma Expleomorphic Adenoma: Observations and Conjectural Study.
Rose GE. et al, (2022), Ophthalmic Plast Reconstr Surg, 38, 563 - 566
Recapitulation of erythropoiesis in congenital dyserythropoietic anaemia type I (CDA-I) identifies defects in differentiation and nucleolar abnormalities.
Scott C. et al, (2021), Haematologica, 106, 2960 - 2970
A remarkable case of HbH disease illustrates the relative contributions of the α-globin enhancers to gene expression.
Badat M. et al, (2021), Blood, 137, 572 - 575
Anti-neutrophil cytoplasmic antibody-positive vasculitis secondary to therapeutic levamisole.
Rose AM., (2020), Rheumatology (Oxford)
Detection of mutations in SF3B1, EIF1AX and GNAQ in primary orbital melanoma by candidate gene analysis.
Rose AM. et al, (2018), BMC Cancer, 18
Cancer and the junkyard chromosome: how repeat DNA sequence on chromosome 19 influences risk of malignant disease.
Rose AM., (2018), Oncotarget, 9, 31942 - 31944
Hb Penang [β78(EF2)Leu→Pro, HBB: c.236T>C]: a Novel β-Globin Variant.
Hsu CH-W. et al, (2018), Hemoglobin, 42, 199 - 202
Multiple primary malignancies and prolonged survival in a patient with widespread metastatic cutaneous melanoma.
Rose AM. et al, (2018), Melanoma Res, 28, 163 - 166
Presentation, Treatment, and Prognosis of Secondary Melanoma within the Orbit.
Rose AM. et al, (2017), Front Oncol, 7
Primary Orbital Melanoma: Presentation, Treatment, and Long-term Outcomes for 13 Patients.
Rose AM. et al, (2017), Front Oncol, 7
Variant haploinsufficiency and phenotypic non-penetrance in PRPF31-associated retinitis pigmentosa.
Rose AM. and Bhattacharya SS., (2016), Clin Genet, 90, 118 - 126