Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The respiratory epithelium is the major interface between the environment and the host. Sophisticated barrier, sensing, anti-microbial and immune regulatory mechanisms have evolved to help maintain homeostasis and to defend the lung against foreign substances and pathogens. During influenza virus infection, these specialised structural cells and populations of resident immune cells come together to mount the first response to the virus, one which would play a significant role in the immediate and long term outcome of the infection. In this review, we focus on the immune defence machinery of the respiratory epithelium and briefly explore how it repairs and regenerates after infection.

Original publication

DOI

10.1016/j.bj.2018.08.004

Type

Journal article

Journal

Biomed J

Publication Date

08/2018

Volume

41

Pages

218 - 233

Keywords

Airway epithelium, Defence, Influenza, Injury and repair, Sensing, Cell Polarity, Chemokines, Cytokines, DEAD Box Protein 58, Humans, Influenza, Human, Interferons, NLR Proteins, Respiratory Mucosa, Tight Junctions, Toll-Like Receptors