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Rearrangements which are most readily explained by homologous crossover between misaligned segments of DNA in the region of the human embryonic zeta (zeta) globin genes have been identified in individuals of three different racial origins. These recombination events have resulted in a surprisingly high prevalence of chromosomes with single (0.4%) and triplicated (1.3%) zeta genes with apparently no significant effect on the phenotype.

Original publication

DOI

10.1093/nar/10.19.5853

Type

Journal article

Journal

Nucleic acids research

Publication Date

10/1982

Volume

10

Pages

5853 - 5868

Keywords

Chromosomes, Human, 16-18, Humans, Thalassemia, DNA Restriction Enzymes, Nucleic Acid Hybridization, Crossing Over, Genetic, Pregnancy, Genes, Continental Population Groups, Female, Embryo, Mammalian