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A study of rheological determinants (plasma viscosity, whole-blood viscosity, and erythrocyte deformability) was made in 24 matched pairs of patients with homozygous sickle cell disease, with and without homozygous alpha-thalassaemia 2. Patients with coexisting alpha-thalassaemia showed a significant increase in erythrocyte deformability measured as filtration of washed erythrocytes through 5 micron diameter pores and also as viscosity of whole blood at high shear rate (230s-1) and standard haematocrit (0.45). This rheological advantage may explain the beneficial effect of alpha-thalassaemia 2 on haematological parameters and clinical events in homozygous sickle cell disease.

Original publication

DOI

10.1111/j.1365-2141.1983.tb02163.x

Type

Journal article

Journal

British journal of haematology

Publication Date

11/1983

Volume

55

Pages

479 - 486

Keywords

Erythrocytes, Humans, Anemia, Sickle Cell, Hemoglobin SC Disease, Thalassemia, Erythrocyte Count, Erythrocyte Indices, Hematocrit, Filtration, Rheology, Blood Viscosity, Homozygote, Pressure, Time Factors, Adolescent, Adult, Aged, Middle Aged, Child, Male