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Two genes, Idd-3 and Idd-4, that influence the onset of autoimmune type 1 diabetes in the nonobese diabetic mouse have been located on chromosomes 3 and 11, outside the chromosome 17 major histocompatibility complex. A genetic map of the mouse genome, analysed using the polymerase chain reaction, has been assembled specifically for the study. On the basis of comparative maps of the mouse and human genomes, the homologue of Idd-3 may reside on human chromosomes 1 or 4 and Idd-4 on chromosome 17.

Original publication

DOI

10.1038/351542a0

Type

Journal article

Journal

Nature

Publication Date

13/06/1991

Volume

351

Pages

542 - 547

Keywords

Animals, Autoimmune Diseases, Chromosome Mapping, Diabetes Mellitus, Experimental, Diabetes Mellitus, Type 1, Genes, Genetic Linkage, Islets of Langerhans, Mice, Mice, Mutant Strains, Pancreatitis, Polymorphism, Restriction Fragment Length, Repetitive Sequences, Nucleic Acid