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In this review, we will highlight the importance of cancer germline antigen-specific cytotoxic CD8+ T lymphocytes (CTL) and the factors affecting antitumor CTL responses. In light of cancer immunotherapy, we will emphasis the need to further understand the features, characteristics, and actions of modulatory receptors of human cancer germline-specific CTLs, in order to determine the optimal conditions for antitumor CTL responses.

Original publication




Journal article


Cell Mol Immunol

Publication Date





684 - 692


T cell receptor, cancer antigen, cytotoxic T cell, immune check point receptor, immune therapy, Antigens, Neoplasm, Cytotoxicity, Immunologic, Epitopes, Germ Cells, Humans, Neoplasms, Receptors, Antigen, T-Cell