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A major unanswered question in the current global coronavirus disease 2019 (COVID-19) outbreak is why severe disease develops in a small minority of infected individuals. In the current article, we report that homozygosity for the C allele of rs12252 in the interferon-induced transmembrane protein 3 (IFITM3) gene is associated with more severe disease in an age-dependent manner. This supports a role for IFITM3 in disease pathogenesis and the opportunity for early targeted intervention in at-risk individuals.

Original publication




Journal article


J Infect Dis

Publication Date





34 - 37


COVID-19, IFITM3, rs12252, severe pneumonia, Adult, Aged, Aged, 80 and over, Alleles, Betacoronavirus, Cohort Studies, Coronavirus Infections, Female, Genotype, High-Throughput Nucleotide Sequencing, Homozygote, Hospitalization, Humans, Male, Membrane Proteins, Middle Aged, Pandemics, Pneumonia, Viral, Polymorphism, Single Nucleotide, RNA-Binding Proteins, Real-Time Polymerase Chain Reaction, Severity of Illness Index