Peter McHugh
D.Phil
Professor of Molecular Oncology
The study of DNA damage and repair to understand the causes of cancer and improve its treatment.
Brief Biography
Director, Oncology Laboratories, WIMM
Head, DNA Damage and Repair Group, Department of Oncology and WIMM
Royal Society Research Fellow, UCL, 2001-2002
Post-Doctoral Fellow, UCL, 1997-2001
D.Phil Biochemistry, University of Oxford 1996
BSc (Hons) Biochemistry, UMIST, 1991
Recent publications
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The dual ubiquitin binding mode of SPRTN secures rapid spatiotemporal proteolysis of DNA-protein crosslinks
Preprint
Song W. et al, (2024)
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SNM1A is crucial for efficient repair of complex DNA breaks in human cells.
Journal article
Swift LP. et al, (2024), Nat Commun, 15
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SNM1A is crucial for efficient repair of complex DNA breaks in human cells
Journal article
MCHUGH P., (2024), Nature Communications
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Cell-active small molecule inhibitors validate the SNM1A DNA repair nuclease as a cancer target
Journal article
Bielinski M. et al, (2024), Chemical Science
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Molecular insights into the stimulation of SNM1A nuclease activity by CSB during interstrand crosslink processing
Preprint
Roddan R. et al, (2024)