Peter McHugh
D.Phil
Professor of Molecular Oncology
The study of DNA damage and repair to understand the causes of cancer and improve its treatment.
Brief Biography
Director, Oncology Laboratories, WIMM
Head, DNA Damage and Repair Group, Department of Oncology and WIMM
Royal Society Research Fellow, UCL, 2001-2002
Post-Doctoral Fellow, UCL, 1997-2001
D.Phil Biochemistry, University of Oxford 1996
BSc (Hons) Biochemistry, UMIST, 1991
Recent publications
-
Neuronal enhancers are hotspots for DNA single-strand break repair.
Journal article
Wu W. et al, (2021), Nature
-
The HelQ human DNA repair helicase utilizes a PWI-like domain for DNA loading through interaction with RPA, triggering DNA unwinding by the HelQ helicase core
Journal article
MCHUGH P. and PTCHELKINE D., (2021), Nucleic Acids Research Cancer
-
Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition
Journal article
Yosaatmadja Y. et al, (2021)
-
Repeat expansions confer WRN dependence in microsatellite-unstable cancers.
Journal article
van Wietmarschen N. et al, (2020), Nature, 586, 292 - 298
-
Characterisation of the SARS-CoV-2 ExoN (nsp14ExoN-nsp10) complex: implications for its role in viral genome stability and inhibitor identification
Journal article
Baddock H. et al, (2020)