Professor of Molecular Oncology
The study of DNA damage and repair to understand the causes of cancer and improve its treatment.
Director, Oncology Laboratories, WIMM
Head, DNA Damage and Repair Group, Department of Oncology and WIMM
Royal Society Research Fellow, UCL, 2001-2002
Post-Doctoral Fellow, UCL, 1997-2001
D.Phil Biochemistry, University of Oxford 1996
BSc (Hons) Biochemistry, UMIST, 1991
Neuronal enhancers are hotspots for DNA single-strand break repair.
Wu W. et al, (2021), Nature
The HelQ human DNA repair helicase utilizes a PWI-like domain for DNA loading through interaction with RPA, triggering DNA unwinding by the HelQ helicase core
MCHUGH P. and PTCHELKINE D., (2021), Nucleic Acids Research Cancer
Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition
Yosaatmadja Y. et al, (2021)
Repeat expansions confer WRN dependence in microsatellite-unstable cancers.
van Wietmarschen N. et al, (2020), Nature, 586, 292 - 298
Characterisation of the SARS-CoV-2 ExoN (nsp14ExoN-nsp10) complex: implications for its role in viral genome stability and inhibitor identification
Baddock H. et al, (2020)