Peter McHugh
D.Phil
Professor of Molecular Oncology
The study of DNA damage and repair to understand the causes of cancer and improve its treatment.
Brief Biography
Director, Oncology Laboratories, WIMM
Head, DNA Damage and Repair Group, Department of Oncology and WIMM
Royal Society Research Fellow, UCL, 2001-2002
Post-Doctoral Fellow, UCL, 1997-2001
D.Phil Biochemistry, University of Oxford 1996
BSc (Hons) Biochemistry, UMIST, 1991
Recent publications
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WRN helicase and mismatch repair complexes independently and synergistically disrupt cruciform DNA structures.
Journal article
Mengoli V. et al, (2022), EMBO J
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Characterization of the SARS-CoV-2 ExoN (nsp14ExoN–nsp10) complex: implications for its role in viral genome stability and inhibitor identification
Journal article
Baddock HT. et al, (2022), Nucleic Acids Research
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A phosphate binding pocket is a key determinant of exo- versus endo-nucleolytic activity in the SNM1 nuclease family.
Journal article
Baddock HT. et al, (2021), Nucleic acids research
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Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition.
Journal article
Yosaatmadja Y. et al, (2021), Nucleic Acids Res
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Neuronal enhancers are hotspots for DNA single-strand break repair.
Journal article
Wu W. et al, (2021), Nature