Professor of Molecular Oncology
The study of DNA damage and repair to understand the causes of cancer and improve its treatment.
Director, Oncology Laboratories, WIMM
Head, DNA Damage and Repair Group, Department of Oncology and WIMM
Royal Society Research Fellow, UCL, 2001-2002
Post-Doctoral Fellow, UCL, 1997-2001
D.Phil, University of Oxford 1996
XPF-ERCC1: Linchpin of DNA crosslink repair
MCHUGH P., (2020), PLoS Genetics
The analysis of DNA interstrand crosslinks and their repair by the modified Comet assay
SWIFT LP. et al, (2020), DNA Electrophoresis: Methods and Protocols., 2119
Microhomologies are prevalent at Cas9-induced larger deletions.
Owens DDG. et al, (2019), Nucleic Acids Res, 47, 7402 - 7417
Optimised oligonucleotide substrates to assay XPF ERCC1 nuclease activity for the discovery of DNA repair inhibitors†
MCHUGH PJ. et al, (2019), Chemical Communications
A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A.
Doherty W. et al, (2019), Org Biomol Chem