Professor of Molecular Oncology
The study of DNA damage and repair to understand the causes of cancer and improve its treatment.
Director, Oncology Laboratories, WIMM
Head, DNA Damage and Repair Group, Department of Oncology and WIMM
Royal Society Research Fellow, UCL, 2001-2002
Post-Doctoral Fellow, UCL, 1997-2001
D.Phil Biochemistry, University of Oxford 1996
BSc (Hons) Biochemistry, UMIST, 1991
A phosphate binding pocket is a key determinant of exo- versus endo-nucleolytic activity in the SNM1 nuclease family.
Baddock HT. et al, (2021), Nucleic acids research
Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition.
Yosaatmadja Y. et al, (2021), Nucleic Acids Res
Neuronal enhancers are hotspots for DNA single-strand break repair.
Wu W. et al, (2021), Nature
The HelQ human DNA repair helicase utilizes a PWI-like domain for DNA loading through interaction with RPA, triggering DNA unwinding by the HelQ helicase core
MCHUGH P. and PTCHELKINE D., (2021), Nucleic Acids Research Cancer
Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition
Yosaatmadja Y. et al, (2021)