DPHIL SUPERVISOR PROFILE
Marella de Bruijn
Professor of Developmental Haematopoiesis
- Director of Graduate Studies
I obtained my BSc in Biomedical Sciences from Leiden University and my PhD from Erasmus University, Rotterdam, the Netherlands, where I trained in Immunology. I was a Post-Doctoral Fellow at the Department of Cell Biology and Genetics at Erasmus University, and a Fellow of the Dutch Cancer Society at Dartmouth Medical School, Hanover, NH. In 2003 I moved to Oxford to join the faculty of the MRC Molecular Haematology Unit at the MRC Weatherall Institute of Molecular Medicine.
My main research interest is the birth of blood stem and progenitor cells during embryonic development. Work in my group focuses on the cellular lineages and gene regulatory networks that underlie the de novo generation of blood stem cells, with the ultimate aim to contribute this knowledge to the development of novel and improved stem cell therapies for regenerative medicine.
As Principal Investigator at the MRC Molecular Haematology Unit, I have trained DPhil students and postdocs, and undergraduates that visit the lab for short projects. Along my research I have been actively involved in coordinating the recruitment, training and supervision of DPhil students, as Director of Graduate Studies at the Radcliffe Department of Medicine and WIMM.
Gata3 targets Runx1 in the embryonic haematopoietic stem cell niche.
Fitch SR. et al, (2020), IUBMB Life, 72, 45 - 52
Microhomologies are prevalent at Cas9-induced larger deletions.
Owens DDG. et al, (2019), Nucleic Acids Res, 47, 7402 - 7417
Blood stem cell-forming haemogenic endothelium in zebrafish derives from arterial endothelium.
Bonkhofer F. et al, (2019), Nat Commun, 10
Kit ligand has a critical role in mouse yolk sac and aorta-gonad-mesonephros hematopoiesis.
Azzoni E. et al, (2018), EMBO Rep, 19
Cell-extrinsic hematopoietic impact of Ezh2 inactivation in fetal liver endothelial cells.
Neo WH. et al, (2018), Blood, 131, 2223 - 2234