Recent publications published by researchers at the MRC WIMM.
Spatiotemporal dynamics of fetal liver hematopoietic niches.
Mesquita Peixoto M. et al, (2025), J Exp Med, 222
A developmental route to hematopoietic stem cells.
Wilkinson AC. and de Bruijn MFTR., (2024), Nat Biotechnol
Tracking early mammalian organogenesis - prediction and validation of differentiation trajectories at whole organism scale.
Imaz-Rosshandler I. et al, (2024), Development, 151
Development of the hematopoietic system
De Bruijn M. and Palis J., (2024), Kaufman's Atlas of Mouse Development Supplement: With Coronal Sections, 145 - 157
Yolk sac cell atlas reveals multiorgan functions during human early development.
Goh I. et al, (2023), Science, 381
GATA2 mitotic bookmarking is required for definitive haematopoiesis.
Silvério-Alves R. et al, (2023), Nat Commun, 14
Dynamic Runx1 chromatin boundaries affect gene expression in hematopoietic development.
Owens DDG. et al, (2022), Nat Commun, 13
The onset of circulation triggers a metabolic switch required for endothelial to hematopoietic transition.
Azzoni E. et al, (2021), Cell Rep, 37
Ezh2 is essential for the generation of functional yolk sac derived erythro-myeloid progenitors.
Neo WH. et al, (2021), Nat Commun, 12
A KMT2A-AFF1 gene regulatory network highlights the role of core transcription factors and reveals the regulatory logic of key downstream target genes.
Harman JR. et al, (2021), Genome Res, 31, 1159 - 1173
The genome-wide impact of trisomy 21 on DNA methylation and its implications for hematopoiesis.
Muskens IS. et al, (2021), Nat Commun, 12
DynamicRunx1chromatin boundaries affect gene expression in hematopoietic development
Owens DDG. et al, (2021)
The T-box transcription factor Eomesodermin governs haemogenic competence of yolk sac mesodermal progenitors.
Harland LTG. et al, (2021), Nat Cell Biol, 23, 61 - 74
EOMESODERMIN GOVERNS THE HEMOGENIC COMPETENCE OF MURINE YOLK-SAC MESODERMAL PROGENITORS
Harland L. et al, (2020), EXPERIMENTAL HEMATOLOGY, 88, S34 - S34
Gata3 targets Runx1 in the embryonic haematopoietic stem cell niche.
Fitch SR. et al, (2020), IUBMB Life, 72, 45 - 52
Microhomologies are prevalent at Cas9-induced larger deletions.
Owens DDG. et al, (2019), Nucleic Acids Res, 47, 7402 - 7417
Blood stem cell-forming haemogenic endothelium in zebrafish derives from arterial endothelium.
Bonkhofer F. et al, (2019), Nat Commun, 10
Kit ligand has a critical role in mouse yolk sac and aorta-gonad-mesonephros hematopoiesis.
Azzoni E. et al, (2018), EMBO Rep, 19
Cell-extrinsic hematopoietic impact of Ezh2 inactivation in fetal liver endothelial cells.
Neo WH. et al, (2018), Blood, 131, 2223 - 2234