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Publications

Recent publications published by researchers at the MRC WIMM.

Tracking early mammalian organogenesis - prediction and validation of differentiation trajectories at whole organism scale.

Imaz-Rosshandler I. et al, (2024), Development, 151

Yolk sac cell atlas reveals multiorgan functions during human early development.

Goh I. et al, (2023), Science, 381

GATA2 mitotic bookmarking is required for definitive haematopoiesis.

Silvério-Alves R. et al, (2023), Nat Commun, 14

Dynamic Runx1 chromatin boundaries affect gene expression in hematopoietic development.

Owens DDG. et al, (2022), Nat Commun, 13

The onset of circulation triggers a metabolic switch required for endothelial to hematopoietic transition.

Azzoni E. et al, (2021), Cell Rep, 37

Ezh2 is essential for the generation of functional yolk sac derived erythro-myeloid progenitors.

Neo WH. et al, (2021), Nat Commun, 12

A KMT2A-AFF1 gene regulatory network highlights the role of core transcription factors and reveals the regulatory logic of key downstream target genes.

Harman JR. et al, (2021), Genome Res, 31, 1159 - 1173

The genome-wide impact of trisomy 21 on DNA methylation and its implications for hematopoiesis.

Muskens IS. et al, (2021), Nat Commun, 12

DynamicRunx1chromatin boundaries affect gene expression in hematopoietic development

Owens DDG. et al, (2021)

The T-box transcription factor Eomesodermin governs haemogenic competence of yolk sac mesodermal progenitors.

Harland LTG. et al, (2021), Nat Cell Biol, 23, 61 - 74

EOMESODERMIN GOVERNS THE HEMOGENIC COMPETENCE OF MURINE YOLK-SAC MESODERMAL PROGENITORS

Harland L. et al, (2020), EXPERIMENTAL HEMATOLOGY, 88, S34 - S34

Gata3 targets Runx1 in the embryonic haematopoietic stem cell niche.

Fitch SR. et al, (2020), IUBMB Life, 72, 45 - 52

Phenotypic analysis of an MLL-AF4 gene regulatory network reveals indirect CASP9 repression as a mode of inducing apoptosis resistance

Harman J. et al, (2020)

Microhomologies are prevalent at Cas9-induced larger deletions.

Owens DDG. et al, (2019), Nucleic Acids Res, 47, 7402 - 7417

Blood stem cell-forming haemogenic endothelium in zebrafish derives from arterial endothelium.

Bonkhofer F. et al, (2019), Nat Commun, 10

Kit ligand has a critical role in mouse yolk sac and aorta-gonad-mesonephros hematopoiesis.

Azzoni E. et al, (2018), EMBO Rep, 19

Cell-extrinsic hematopoietic impact of Ezh2 inactivation in fetal liver endothelial cells.

Neo WH. et al, (2018), Blood, 131, 2223 - 2234

Transcriptional regulation of Hhex in hematopoiesis and hematopoietic stem cell ontogeny.

Migueles RP. et al, (2017), Dev Biol, 424, 236 - 245

Runx transcription factors in the development and function of the definitive hematopoietic system.

de Bruijn M. and Dzierzak E., (2017), Blood, 129, 2061 - 2069

Disruption of the aortic wall by coelomic lining-derived mesenchymal cells accompanies the onset of aortic hematopoiesis.

Arraf AA. et al, (2017), Int J Dev Biol, 61, 329 - 335

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