Research groups
Websites
-
MRC Human Immunology Unit
Research Unit
-
MRC Weatherall Institute of Molecular Medicine
Research Institute
Jan Rehwinkel
PhD
Professor of Innate Immunology
Nucleic acid sensing by innate immune receptors
Jan is interested in the molecular mechanisms underlying host-pathogen interactions. In particular, Jan studies how cells detect virus infection. His work lies at the intersection of immunology, virology and molecular biology. After undergraduate training in biology at the University of Heidelberg, Germany, Jan joined the European Molecular Biology Laboratory (EMBL) as a PhD student. Under supervision of Elisa Izaurralde, Jan studied post-transcriptional control of messenger RNA, including the mechanisms by which microRNAs repress their targets, and obtained a PhD in 2007. This background in RNA biology led Jan to develop an interest in nucleic acids in innate immunity. As a postdoctoral fellow, he joined the group of Caetano Reis e Sousa, then at the Cancer Research UK London Research Institute (London, UK). Jan investigated how RNA viruses such as influenza A virus are recognised by innate immune sensors, particularly RIG-I. In 2012, Jan moved to the University of Oxford, UK, to establish his independent research group. His laboratory is part of the MRC Human Immunology Unit and the MRC Weatherall Institute of Molecular Medicine. Jan's research dissects nucleic acid sensing by innate receptors in the context of virus infection, autoinflammatory disease and cancer. Jan's work is funded by the MRC, Wellcome Trust, Lister Institute and European Union.
Key publications
-
Restriction by SAMHD1 Limits cGAS/STING-Dependent Innate and Adaptive Immune Responses to HIV-1.
Journal article
Maelfait J. et al, (2016), Cell Rep, 16, 1492 - 1501
-
Viruses transfer the antiviral second messenger cGAMP between cells.
Journal article
Bridgeman A. et al, (2015), Science, 349, 1228 - 1232
-
RIG-I detects viral genomic RNA during negative-strand RNA virus infection.
Journal article
Rehwinkel J. et al, (2010), Cell, 140, 397 - 408
Recent publications
-
Regulation and inhibition of the DNA sensor cGAS.
Journal article
Hertzog J. and Rehwinkel J., (2020), EMBO Rep
-
Mutations in COPA lead to abnormal trafficking of STING to the Golgi and interferon signaling.
Journal article
Lepelley A. et al, (2020), J Exp Med, 217
-
Hypoxia induces transcriptional and translational downregulation of the type I interferon (IFN) pathway in multiple cancer cell types.
Journal article
Miar A. et al, (2020), Cancer Res
-
Author Correction: SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate.
Journal article
Olagnier D. et al, (2020), Nat Commun, 11
-
SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate.
Journal article
Olagnier D. et al, (2020), Nat Commun, 11