MRC Clinician Scientist and Honorary Consultant Haematologist
I am a clinician scientist with a specialist interest in haemopoietic stem cell transplantation, genome editing, genomics and bioinformatics. I studied medicine at Oxford University before going on to complete specialist training in haematology and intensive care medicine in London. At present I have an MRC Clinician Scientist Fellowship and I am setting up a group at the Weatherall Institute of Molecular Medicine. In addition, I am an honorary consultant haematologist with the allogeneic transplant service in Oxford.
My research focuses on developing novel next generation sequencing-based methods for interrogating how the genome functions and leveraging this to develop methods of genome editing bone marrow derived stem cells. I have a particular interest in developing methods that allow the physical structure of DNA in the nucleus to be defined. With Jim Hughes and Doug Higgs I developed the Capture-C method. This technique lead to insights into how genes are controlled and I was awarded the RDM Graduate Prize for this project. I am also interested in using genome editing of bone marrow derived stem cells to treat disease. In particular, I am using my previous expertise in bioinformatics to and high throughput sequencing to develop new ways of defining off target effects from genome editing.
Single-cell analysis of bone marrow-derived CD34+ cells from children with sickle cell disease and thalassemia.
Hua P. et al, (2019), Blood, 134, 2111 - 2115
An integrated platform to systematically identify causal variants and genes for polygenic human traits
Downes D. et al, (2019)
The bipartite TAD organization of the X-inactivation center ensures opposing developmental regulation of Tsix and Xist.
van Bemmel JG. et al, (2019), Nat Genet, 51, 1024 - 1034
Single-allele chromatin interactions identify regulatory hubs in dynamic compartmentalized domains.
Oudelaar AM. et al, (2018), Nat Genet, 50, 1744 - 1751
Expression of the Human Alpha-Globin Cluster in the Absence of the Major Regulatory Element Mcs-R2
Badat M. et al, (2018), BLOOD, 132