DPHIL PROJECTS AVAILABLE
We're really keen to have great DPhil students in the lab. We have projects available in three main areas.
Genome editing - projects aiming to develop useful editing strategies for treating patients.
Genomics - projects aiming to develop novel techniques to interrogate how the genome functions.
Bioinformatics - projects to develop new computational methods to interrogate genomics data.
Associate Professor of Genomics
- MRC Clinician Scientist
- Honorary Consultant Haematologist
I am a clinician scientist with a specialist interest in haemopoietic stem cell transplantation, genome editing, genomics and bioinformatics. I studied medicine at Oxford University before going on to complete specialist training in haematology and intensive care medicine in London. I have an MRC Clinician Scientist Fellowship and my group is based at the MRC Weatherall Institute of Molecular Medicine. In addition, I am an honorary consultant haematologist with the allogeneic transplant service in Oxford.
My research focuses on developing novel next generation sequencing-based methods for interrogating how the genome functions and leveraging this to develop methods of genome editing bone marrow derived stem cells. I have a particular interest in developing methods that allow the physical structure of DNA in the nucleus to be defined. The way in which chromatin is folded is one of the key determinants of gene expression. We leverage our understanding of how the genome functions to develop novel strategies of editing blood and bone marrow derived cells to treat human disease. In particular, we are interested in using our expertise in developing high throughput sequencing assays and bioinformatics to develop new ways of defining the off-target effects caused by genome editing.
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High-resolution targeted 3C interrogation of cis-regulatory element organization at genome-wide scale.
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BET inhibition disrupts transcription but retains enhancer-promoter contact.
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