Contact information
Research groups
Websites
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MRC Human Immunology Unit
Research Unit
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MRC Weatherall Institute of Molecular Medicine
Research Institute
Graham Ogg
Professor of Dermatology
Skin immunology; T cells; innate lymphoid cells
Skin and mucosae frequently represent the first point of contact with pathogens and allergens, yet we still know relatively little of the role of the surface immune system in clearing such challenges. This is crucially important in understanding the mechanisms of skin diseases and related diseases, and for optimising approaches to cutaneous drug and vaccine delivery. The aim of the group is therefore to understand, at the molecular and cellular level, the role of human cutaneous immune responses in mechanisms of disease, treatment and vaccination. As well as contributing to an understanding of disease pathogenesis, we aim to translate our findings to changes in clinical practice.
Recent publications
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HLA-dependent variation in SARS-CoV-2 CD8+ T cell cross-reactivity with human coronaviruses.
Journal article
Buckley PR. et al, (2022), Immunology
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Phospholipase activity of Acyloxyacyl Hydrolase induces IL‐22‐producing CD1a‐autoreactive T cells in individuals with psoriasis
Journal article
Singh R. et al, (2021), European Journal of Immunology
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An immunodominant NP105-113-B*07:02 cytotoxic T cell response controls viral replication and is associated with less severe COVID-19 disease.
Journal article
Peng Y. et al, (2021), Nat Immunol
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Surveillance of SARS-CoV-2 variants of concern by identification of single nucleotide polymorphisms in the spike protein by a multiplex real-time PCR.
Journal article
Gomes L. et al, (2021), J Virol Methods, 300
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British Association of Dermatologists guidelines for the management of people with chronic urticaria 2021.
Journal article
Sabroe RA. et al, (2021), Br J Dermatol