Professor of Dermatology
Skin immunology; T cells; innate lymphoid cells
Skin and mucosae frequently represent the first point of contact with pathogens and allergens, yet we still know relatively little of the role of the surface immune system in clearing such challenges. This is crucially important in understanding the mechanisms of skin diseases and related diseases, and for optimising approaches to cutaneous drug and vaccine delivery. The aim of the group is therefore to understand, at the molecular and cellular level, the role of human cutaneous immune responses in mechanisms of disease, treatment and vaccination. As well as contributing to an understanding of disease pathogenesis, we aim to translate our findings to changes in clinical practice.
Innate Lymphocyte Mechanisms in Skin Diseases.
Chen Y-L. et al, (2020), 38, 171 - 202
Re-evaluation of human BDCA-2+ DC during acute sterile skin inflammation.
Chen Y-L. et al, (2020), J Exp Med, 217
Natural killer cells get under your skin.
Ogg G., (2020), Sci Transl Med, 12
Association of dengue virus-specific polyfunctional T-cell responses with clinical disease severity in acute dengue infection.
Wijeratne DT. et al, (2019), Immun Inflamm Dis, 7, 276 - 285
Resistance to apoptosis underpins the corticosteroid insensitivity of group 2 innate lymphoid cells.
Luo J. et al, (2019), J Allergy Clin Immunol, 144, 1722 - 1726.e10