Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Two awards have been announced for scientists in the WIMM.

 

oni_chowdhury

Oni Chowdhury has been awarded an NIHR clinical lectureship. This will enable Oni to incorporate the remainder of her specialist clinical training with research. She will be working on the therapeutic targeting of malignant stem cells with the Stem Cell Group in the WIMM.

648A3130

Chris Babbs has been awarded a 3 year project grant, funded by Action Medical Research for Children, to identify new alleles and genes underlying Congenital Dyserythropoietic Anaemia type I, a variable anaemia that manifests in childhood. Coding mutations in the genes previously shown to underlie this disease explain only ~60% of cases, strongly suggesting the presence of occult pathogenic alleles or the involvement of a further locus. Identification of further genetic lesions will improve molecular diagnosis and is likely to shed light on the pathogenic mechanism underlying this disorder. The defining cellular characteristic of this anaemia is abnormal chromatin formation in erythroblast nuclei, suggesting that all causative mutations affect a pathway critical for chromatin assembly or compaction in maturing erythroblasts. By introducing specific mutations into induced pluripotent stem cells we hope to shed light on the pathogenic mechanism and establish a high throughput screening system to test small molecules as potential therapy for this disorder.

Congratulations to both of them.

Similar stories

Nucleome Therapeutics raises oversubscribed £37.5 million Series A financing

The biotechnology company builds upon research conducted by Professor Jim Hughes and Prof. James Davies at the MRC Weatherall Institute of Molecular Medicine, and combines 3D genome technology and machine learning to decode the dark matter of the human genome.

KJ Patel appointed new Chief Scientist of CRUK

Alongside his new role at Cancer Research UK, Prof. Patel will continue as the Director of both the MRC Weatherall Institute for Molecular Medicine (MRC WIMM) and the MRC Molecular Haematology Unit (MRC MHU).

September is Childhood Cancer Awareness Month

September is Childhood Cancer Awareness Month, where our Childhood Leukaemia research group have taken action to help raise awareness for this cause.

Wellcome Trust funding success for Jim Hughes and James Davies

£3.6 million in funding awarded by the Wellcome Trust to combine cutting-edge 3D genome technologies with machine learning approaches to decipher the role of the non-coding genome in disease.