Oxford scientists map the cells that drive Crohn’s disease fistulas
Researchers at the MRC Translational Immune Discovery Unit have identified how rare populations of abnormal cells drive the formation and persistence of fistulas - painful, tunnel-like tracts that develop in around 30% of people with Crohn’s disease - paving the way for targeted treatments.
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MRC Translational Immune Discovery Unit
Pioneering the future in the study of human immunity to uncover the molecular pathways driving immune-mediated diseases.
MRC Molecular Haematology Unit
Understanding how mature blood cells are normally made from stem cells and how this is perturbed in common blood disorders.
Centre for Computational Biology
Using computational biology to help understand complex biological systems and combat a range of human diseases.
Latest publications
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Spatial fibroblast niches define Crohn's fistulae.
Journal article
McGregor C. et al, (2025), Nature
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Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions.
Journal article
Li H. et al, (2025), Cell
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Genetic determinants of monocyte splicing are enriched for disease susceptibility loci.
Journal article
Nassiri I. et al, (2025), Nat Commun, 16