Charting New Paths in Cancer Research: Insights from the Frontiers in Cancer Science Conference 2024.
Le Minh G., Lucky SS., Pervaiz S., Ramadan K., Yeong J., Ong ST., Krishnan V., Cheok CF., Chng WJ., De Mel S., Wang X., Jeyasekharan AD., Tipgomut C., Kong LR., Sabapathy K., Chee CE., Itahana K., Taneja R., Lee S-C.
The 16th annual Frontiers in Cancer Science conference convened leading experts to discuss the latest developments in cancer research. Key research themes included mechanisms of treatment resistance and innovative strategies to target resistant cancer cells, metabolic plasticity and its therapeutic vulnerabilities, modulation of the tumor microenvironment to enhance therapeutic efficacy, recent advances in immunotherapies and engineered immune cells, and strategies to overcome tumor immune evasion. The conference also highlighted the development of advanced spatial transcriptomic technologies as a powerful tool to decipher tumor heterogeneity and identify novel therapeutic targets. Additionally, the transformative potential of artificial intelligence and machine learning was explored in optimizing therapy selection, refining prognostication models, and improving patient outcomes, with a focus on advancing personalized, cost-effective cancer care. These collective insights underscore the rapid progress in the field and the potential for translating these discoveries into effective clinical interventions, marking a significant step toward addressing the complexities of cancer biology and enhancing patient care worldwide.