Beyond cancer dependency maps: the PRECISE vision
Dr Sumana Sharma is one of the founding partners of a major new pan-European initiative that aims to transform how scientists identify and target cancer's weaknesses, moving beyond simply mapping cancer vulnerabilities towards predicting them before they are experimentally tested.
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MRC Translational Immune Discovery Unit
Pioneering the future in the study of human immunity to uncover the molecular pathways driving immune-mediated diseases.
MRC Molecular Haematology Unit
Understanding how mature blood cells are normally made from stem cells and how this is perturbed in common blood disorders.
Centre for Computational Biology
Using computational biology to help understand complex biological systems and combat a range of human diseases.
Latest publications
Loss of cellular RNA homeostasis contributes to MDA5 activation during virus infection.
Journal article
Sampaio NG. et al, (2026), Nat Immunol
α-Synuclein blocks endoplasmic reticulum co-translational protein translocation early in Parkinson's disease.
Journal article
Lam CL. et al, (2026), Nat Commun, 17
Gut microbiota restricts intestinal lipid uptake via modulation of bile phosphatidylcholine metabolism in mice.
Journal article
Brunner S. et al, (2026), Nat Microbiol, 11, 2349 - 2364
Enforcing mTORC1 activity in therapeutic CD4+ T cells promotes persistence but eventual immune exhaustion.
Journal article
Sillito F. et al, (2026), Journal of immunology (Baltimore, Md. : 1950), 215
The Thrombopoietin Receptor S264F Mutant Drives MPN with Marrow Fibrosis Through a Dual Mechanism
Journal article
MEAD A., (2026), HemaSphere
Upcoming Seminars
What Defines An Outstanding Scientific Job Application: An Insider Panel Discussion on Scientific Careers in the Age of AI
Thursday, 20 August 2026, 3pm to 4pm
Speaker(s): Prf Anne Goriely (University of Oxford), Dr Elisa Rosati Scalchi (Immunespec), Prof Hashem Koohy (University of Oxford)
Series: Immunity By Design
Protein-protein interaction networks of leukemia
Tuesday, 01 September 2026, 1pm to 2pm
Speaker(s): Akhihiko Yokoyama
Venue:
MRC Weatherall Institute of Molecular Medicine - Seminar Room
Seminar Room MRC Weatherall Institute of Molecular Medicine Headington Oxford Oxfordshire OX3 9DS United Kingdom
Series: Molecular Haematology Unit
Therapeutic targeting of epigenetic enzymes in haematological malignancies
Tuesday, 22 September 2026, 1pm to 2pm
Speaker(s): Professor Tim Somervaille
Venue:
MRC Weatherall Institute of Molecular Medicine - WIMM Seminar room
WIMM Seminar room MRC Weatherall Institute of Molecular Medicine Headington Oxford Oxfordshire OX3 9DS United Kingdom
Venue details:
WIMM Seminar Room
Series: Molecular Haematology Unit, WIMM
Somatic mutations in ageing and disease
Tuesday, 06 October 2026, 1pm to 2pm
Speaker(s): Inigo Martincorena (Wellcome Sanger Institute)
Series: Molecular Haematology Seminar Series