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Beyond cancer dependency maps: the PRECISE vision

Dr Sumana Sharma is one of the founding partners of a major new pan-European initiative that aims to transform how scientists identify and target cancer's weaknesses, moving beyond simply mapping cancer vulnerabilities towards predicting them before they are experimentally tested.

Banner image featuring the words a leader in translating research from bench to clinic, next to an image of a scientist pipetting a pink liquid.

Translating Our Research

Leading research with the aim of improving human health. World-leading research from scientists at the MRC WIMM has been developed into commercial ventures to translate our discoveries into clinics and benefit patients.

The MRC WIMM Green Impact team with the Gold Green Impact award.

MRC WIMM achieves Gold Green Impact award

Congratulations to the Institute's Green Impact team, who achieved Gold in the University of Oxford's 2026 Green Impact awards.

MRC WIMM Research Areas

Research at the MRC WIMM spans 5 core areas.

The image depicts CAR T cells killing malignant bone marrow cells that are expressing mutant CALR, illustrated as a red ‘flag’ on the cell surface.

New personalised therapy targets chronic blood cancer

A new form of CAR T cell therapy has been designed to find and destroy the cancer-driving cells responsible for a group of blood cancers known as myeloproliferative neoplasms (MPNs), while leaving healthy blood cells unharmed, according to a new study led by UCL and University of Oxford researchers.

Discover. Translate. Advance.

The MRC WIMM's core mission is to improve human health through the pursuit of fundamental research, the development of new technology, and the translation of discoveries to the clinic.

MRC Translational Immune Discovery Unit

Pioneering the future in the study of human immunity to uncover the molecular pathways driving immune-mediated diseases.

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MRC Molecular Haematology Unit

Understanding how mature blood cells are normally made from stem cells and how this is perturbed in common blood disorders.

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Centre for Computational Biology

Using computational biology to help understand complex biological systems and combat a range of human diseases.

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Magrolimab Plus Azacitidine Versus Placebo Plus Azacitidine in Patients With Untreated Higher-Risk Myelodysplastic Syndromes: The Phase III ENHANCE Study.

Sallman DA. et al, (2026), J Clin Oncol

Transcriptomic analysis of tissue-resident memory T cells of the fallopian tube reveals a precursor immune surveillance network for ovarian cancer prevention.

Wang L. et al, (2026), Nat Commun

More Publications

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MRC WIMM Interactive Timeline

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Beyond cancer dependency maps: the PRECISE vision

Translating Our Research

MRC WIMM achieves Gold Green Impact award

MRC WIMM Research Areas

New personalised therapy targets chronic blood cancer

Discover. Translate. Advance.

MRC Translational Immune Discovery Unit

MRC Molecular Haematology Unit

Centre for Computational Biology

Latest publications

The Thrombopoietin Receptor S264F Mutant Drives MPN with Marrow Fibrosis Through a Dual Mechanism

Nucleophagy as an emerging therapeutic vulnerability in cancer.

The effect of cohesin mutations on HLA-class II expression in the myeloid leukemia of Down syndrome.

Magrolimab Plus Azacitidine Versus Placebo Plus Azacitidine in Patients With Untreated Higher-Risk Myelodysplastic Syndromes: The Phase III ENHANCE Study.

Transcriptomic analysis of tissue-resident memory T cells of the fallopian tube reveals a precursor immune surveillance network for ovarian cancer prevention.

MRC WIMM Interactive Timeline

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Beyond cancer dependency maps: the PRECISE vision

MRC Translational Immune Discovery Unit

MRC Molecular Haematology Unit

Centre for Computational Biology

Latest publications

The Thrombopoietin Receptor S264F Mutant Drives MPN with Marrow Fibrosis Through a Dual Mechanism

Nucleophagy as an emerging therapeutic vulnerability in cancer.

The effect of cohesin mutations on HLA-class II expression in the myeloid leukemia of Down syndrome.

Magrolimab Plus Azacitidine Versus Placebo Plus Azacitidine in Patients With Untreated Higher-Risk Myelodysplastic Syndromes: The Phase III ENHANCE Study.

Transcriptomic analysis of tissue-resident memory T cells of the fallopian tube reveals a precursor immune surveillance network for ovarian cancer prevention.

MRC WIMM Interactive Timeline