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Researcher hanlding patient samples in a lab.

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Reversing T cell exhaustion improves effectiveness of myeloma immunotherapies

Researchers at the Icahn School of Medicine at Mount Sinai, Bristol Myers Squibb (BMS), and the University of Oxford have discovered a way to give worn-out immune cells a second wind in the fight against multiple myeloma.

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Banner image featuring the words a leader in translating research from bench to clinic, next to an image of a scientist pipetting a pink liquid.

Translating Our Research

Leading research with the aim of improving human health. World-leading research from scientists at the MRC WIMM has been developed into commercial ventures to translate our discoveries into clinics and benefit patients.

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Fluorescent imaging of a zebrafish embryo highlights cell populations during early development. The image reflects the type of dynamic biological system researchers used to test RegVelo, a new AI framework for predicting how cells acquire their identities and identifying the genetic regulators that guide them.

© Stowers Institute for Medical Research

New AI model predicts how cells choose their fate

Researchers from the University of Oxford, the Stowers Institute for Medical Research, Helmholtz Munich, and the Technical University of Munich have developed a new artificial intelligence framework that helps uncover how cells make developmental decisions.

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Research at the MRC WIMM spans 5 core areas.

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MRC WIMM Research Areas

Research at the MRC WIMM spans 5 core areas.

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Deputy Directors of the MRC Weatherall Institute of Molecular Medicine

Professor Adam Mead is joining Professor Alison Simmons as a Deputy Director of the WIMM in May 2026.

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The MRC WIMM's core mission is to improve human health through the pursuit of fundamental research, the development of new technology, and the translation of discoveries to the clinic.

Discover. Translate. Advance.

The MRC WIMM's core mission is to improve human health through the pursuit of fundamental research, the development of new technology, and the translation of discoveries to the clinic.

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MRC Translational Immune Discovery Unit

Pioneering the future in the study of human immunity to uncover the molecular pathways driving immune-mediated diseases.

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MRC Molecular Haematology Unit

Understanding how mature blood cells are normally made from stem cells and how this is perturbed in common blood disorders.

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Centre for Computational Biology

Using computational biology to help understand complex biological systems and combat a range of human diseases.

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Latest publications

TiO2 Alternative Coatings for Ferric Pyrophosphate Premixes: Stability and Bioaccessibility Relative to Ferrous Fumarate

Teichman DL. et al, (2026), Innovative Food Science and Emerging Technologies, 111

PD-1 signaling and PD-1 blockade-mediated tumor control are established at microvillar T cell contacts.

Jenkins E. et al, (2026), Sci Immunol, 11

Mezigdomide reverses T-cell exhaustion through degradation of IKZF1/IKZF3 and reinvigoration of cytokine production pathways.

Chiu H. et al, (2026), Blood

Ikaros degradation by mezigdomide reduces T-cell dysfunction and improves the efficacy of antimyeloma T-cell therapies.

Chen LY. et al, (2026), Blood

Early-life Wnt4 expressing colon stromal cells orchestrate lifelong mucosal homeostasis via BMP-driven iNKT cell imprinting.

Lin X. et al, (2026), Nat Commun

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Upcoming Seminars

DNA damage, cancer and aging and the unexpected impact of nutrition and gene length

Thursday, 21 May 2026, 12pm to 1pm

Speaker(s): Professor Jan Hoeijmakers

Series: WIMM THURSDAY SEMINARS

Postnatal reprogramming shapes human intestinal epithelial immune competency

Friday, 22 May 2026, 9.15am to 10.15am

Speaker(s): Dr Chloe Hyun-Jung Lee, Simmons Group

Series: MRC TIDU Friday Morning Lab Meetings

Infections, vaccines, and brain health

Friday, 29 May 2026, 9.15am to 10.15am

Speaker(s): Prof Maxime Taquet

Series: MRC TIDU Friday Morning Lab Meetings

Scalable Tools to Map T Cell Recognition

Monday, 01 June 2026, 3pm to 4pm

Speaker(s): Dr Stephanie Gaglione (Gladstone Institute)

Series: Unravelling T Cell Recognition: Insights from Immunology and AI

More Seminars

MRC WIMM Interactive Timeline

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