Paula Gomez Castro
DPhil Student in Medical Sciences
My research focuses on G protein-coupled receptors involved in the regulation of vascular remodelling and tissue repair in IBD, with the aim to identify effective and innovative targets for the treatment of chronic inflammatory diseases.
I'm exploring GPCRs that drive pathological endothelial functions in IBD, such as increased vascular permeability, enhanced leukocyte recruitment, and pathological angiogenesis. These processes are key drivers of disease progression and impaired wound healing. My aim is to understand the molecular mechanisms underlying these and to identify therapeutic targets that not only reduce inflammation but also address the underlying tissue damage and restore intestinal barrier integrity.
Beyond the lab I'm involved with OUBT Consulting as a Project Leader and also work as a freelance consultant in the Life Sciences sector. Outside of research I enjoy live music, playing badminton, and exploring hidden gems in cities.
Recent publications
Spatial fibroblast niches define Crohn's fistulae.
Journal article
McGregor C. et al, (2026), Nature, 649, 703 - 712
Author Correction: Spatial fibroblast niches define Crohn's fistulae.
Journal article
McGregor C. et al, (2025), Nature, 648
Changes in intestinal permeability and gut microbiota following diet-induced weight loss in patients with metabolic dysfunction-associated steatohepatitis and liver fibrosis.
Journal article
Koutoukidis DA. et al, (2024), Gut Microbes, 16