Lauren Murphy
Postdoctoral Researcher
I am a postdoctoral researcher in the Psaila Lab, having recently completed my DPhil under the supervision of Prof. Beth Psaila.
During my DPhil, I uncovered the unexpected finding that human platelets harbour a repertoire of DNA fragments spanning the nuclear genome. This discovery led us to validate tumour-educated platelets as a liquid biopsy biomarker, enabling non-invasive molecular profiling of cancer.
My current research builds on this work and explores why platelets sequester DNA, with the broader aim of understanding the biological significance of platelet–nucleic acid interactions and how this might feed into cell-cell communication.
Recent publications
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A proinflammatory stem cell niche drives myelofibrosis through a targetable galectin-1 axis.
Journal article
Li R. et al, (2024), Sci Transl Med, 16
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Cross-Talk between Hematopoietic Cells and Fibroblast Subsets Drives Inflammation and Remodelling of the Bone Marrow Microenvironment in Myeloproliferative Neoplasms
Conference paper
Li R. et al, (2022), BLOOD, 140, 1091 - 1092
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Familial thrombocytopenia: The long and short of it.
Journal article
Murphy L. and Mead AJ., (2021), J Exp Med, 218