Contact information

Telephone
+44 (0)1865 222316
Lab: +44 (0)1865222419

PA
Fardowsi Kazi (Paediatrics: fardowsi.kazi@paediatrics.ox.ac.uk); Fiona Lambert (MRC MHU, WIMM)
fiona.lambert@imm.ox.ac.uk

Research groups

Anindita Roy

MRCPCH FRCPath PhD

Professor of Paediatric Haematology

Wellcome Trust Clinical Research Career Development Fellow
MRC Investigator
Honorary Paediatric Haematology Consultant, Great Ormond Street Hospital London

Main research interest: understanding the origins and biology of childhood leukaemia.

Biography

Previous academic placements: LLR Clinical Training Fellowship/PhD (2007-2011) Imperial College London. NIHR Academic Clinical Lectureship in Paediatric Haematology (2011-2015) Imperial College London. Bloodwise Clinician Scientist (2015-2020) at University of Oxford.

Clinical training: MBBS and postgraduate Paediatric training, Christian Medical College Vellore, India. Paediatric training (SHO and SpR), London, UK. Integrated Academic Clinical Training programme in Paediatric Haematology, London, UK

Research focus

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ONGOING D.PHIL PROJECTS

The developmental stage-specific cellular and molecular characteristics of fetal and postnatal progenitors are likely to determine the biology of ALL at different ages. We are particularly interested in high-risk childhood ALL, such as infant ALL and Down syndrome associated ALL. We have recently developed a novel MLL-AF4+ infant ALL model using primary human haematopoietic stem and progenitor cells. The overarching aim of research in our lab is to improve the outcomes of children with high-risk ALL. The current DPhil projects are in these areas:

1) Developing faithful models of high-risk childhood ALL to better understand leukaemia initiation and maintenance at different ages

2) Mechanistic studies to understand key drivers of childhood ALL

3) Target discovery and translation of findings from (1) and (2) into preclinical studies

4) Projects using multi-omics to understand how cell intrinsic and/or microenvironmental characteristics of the developmental stage at which a leukaemia originates, drives the biology of leukaemia at different ages