Natalie Jooss
Postdoctoral Scientist and Programme Manager
I am a postdoctoral scientist in the Psaila Lab and support programme management across the Psaila and Mead laboratories.
Trained as a platelet biologist, I completed a joint double PhD degree at Maastricht University and the University of Birmingham through a Horizon 2020 Marie Skłodowska-Curie Innovative Training Network (ITN) in 2022. Following this, I joined the University of Oxford as a postdoctoral scientist investigating a group of rare blood cancers called myeloproliferative neoplasms (MPNs).
My research focuses on the role of Galectin-1 within the bone marrow niche and circulating platelets in MPNs.
In particular, my work explores:
i) the contribution of Galectin-1 to the prothrombotic phenotype observed in MPN patients, and
ii) its impact on the bone marrow microenvironment, particularly in relation to megakaryocytes, mast cells, and basophils.
In addition to my research activities, I am involved in programme coordination and oversee broader laboratory management.
Recent publications
Platelets sequester extracellular DNA, capturing tumor-derived and free fetal DNA.
Journal article
Murphy L. et al, (2025), Science, 389
Selective Btk inhibition by PRN1008/PRN473 blocks human CLEC-2, and PRN473 reduces venous thrombosis formation in mice.
Journal article
Smith CW. et al, (2024), Blood Adv, 8, 5557 - 5570
A proinflammatory stem cell niche drives myelofibrosis through a targetable galectin-1 axis.
Journal article
Li R. et al, (2024), Sci Transl Med, 16
Generating human bone marrow organoids for disease modeling and drug discovery.
Journal article
Olijnik A-A. et al, (2024), Nat Protoc, 19, 2117 - 2146
Restraining of glycoprotein VI- and integrin α2β1-dependent thrombus formation by platelet PECAM1.
Journal article
Jooss NJ. et al, (2024), Cell Mol Life Sci, 81