Recent publications published by researchers at the MRC WIMM.
Detecting and quantifying clonal selection in somatic stem cells.
Körber V. et al, (2025), Nat Genet
PROM1/CD133 MARKS A PROLIFERATIVE STEM CELL LIKE POPULATION OF BLASTS IN KMT2A REARRANGED INFANT ALL.
Cross JW. et al, (2025), Blood Adv
Plants monitor the integrity of their barrier by sensing gas diffusion.
Iida H. et al, (2025), Nature
Silencing of SOD1 sensitises ATRX-deficient cells to camptothecin treatment through increased activity of the Alternative Lengthening of Telomeres pathway
ROSE A. et al, (2025), Human Molecular Genetics
Clinical significance of preleukemic somatic GATA1 mutations in children with Down syndrome.
Elliott N. et al, (2025), Blood
Iron deficiency causes aspartate-sensitive dysfunction in CD8+ T cells.
Teh MR. et al, (2025), Nat Commun, 16
Engineering antisense oligonucleotides for targeted mRNA degradation through lysosomal trafficking.
Kashyap D. et al, (2025), Chem Sci
REnformer, a single-cell ATAC-seq predicting model to investigate open chromatin sites
Riva SG. et al, (2025)
Genome-Wide Association Studies of Down Syndrome Associated Congenital Heart Defects Suggests a Genetically Heterogeneous Risk for CHD in DS.
Feldman ER. et al, (2025), Genet Epidemiol, 49
Measure selection for an electronic patient-reported outcome (ePRO) system for CAR T-cell therapy patients: a modified Delphi consensus study
Hughes SE. et al, (2025), Eclinicalmedicine, 84
Validation of the "Patient-Acceptable Symptom State" Question as Outcome Measure in AChR Myasthenia Gravis: A Multicentre, Prospective Study.
Spagni G. et al, (2025), Eur J Neurol, 32
Oxford Classic-defined EMT risk stratification of High Grade Serous Ovarian cancer for guiding treatment decisions
AHMED A., (2025), Clinical Cancer Research
Immune perturbation by the ileal microbiota in multiple sclerosis.
Jensen LT. and Fugger L., (2025), Proc Natl Acad Sci U S A, 122
A Revised Prognostic Model for Patients with Acute Myeloid Leukemia and First Relapse.
Van Der Maas NG. et al, (2025), Blood Adv
Clonal tracing with somatic epimutations reveals dynamics of blood ageing.
Scherer M. et al, (2025), Nature