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Publications

Recent publications published by researchers at the MRC WIMM.

The case of the missing Ks: Base editor screen to assess cellular fitness at single lysines.

Gopala Krishna V. et al, (2023), Mol Cell, 83, 4442 - 4444

Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation.

Chen Z. et al, (2022), Cell Death Differ, 29, 1955 - 1969

Sequence and structural variations determining the recruitment of WNK kinases to the KLHL3 E3 ligase.

Chen Z. et al, (2022), Biochem J, 479, 661 - 675

The NUCKS1-SKP2-p21/p27 axis controls S phase entry.

Hume S. et al, (2021), Nat Commun, 12

The role of E3 ubiquitin ligases in the development and progression of glioblastoma.

Humphreys LM. et al, (2021), Cell Death Differ, 28, 522 - 537

Identification of a PGXPP degron motif in dishevelled and structural basis for its binding to the E3 ligase KLHL12.

Chen Z. et al, (2020), Open Biol, 10

E2F1: Cause and Consequence of DNA Replication Stress.

Fouad S. et al, (2020), Front Mol Biosci, 7

Identification of a PGXPP degron motif in dishevelled and structural basis for its binding to the E3 ligase KLHL12

Chen Z. et al, (2020)

E2F1 proteolysis via SCF-cyclin F underlies synthetic lethality between cyclin F loss and Chk1 inhibition.

Burdova K. et al, (2019), EMBO J, 38

Structural Basis for Recruitment of DAPK1 to the KLHL20 E3 Ligase.

Chen Z. et al, (2019), Structure, 27, 1395 - 1404.e4

Cullin Ring Ubiquitin Ligases (CRLs) in Cancer: Responses to Ionizing Radiation (IR) Treatment.

Fouad S. et al, (2019), Front Physiol, 10

Cyclin F-Chk1 synthetic lethality mediated by E2F1 degradation

Burdova K. et al, (2019)

β-TrCP- and Casein Kinase II-Mediated Degradation of Cyclin F Controls Timely Mitotic Progression.

Mavrommati I. et al, (2018), Cell Rep, 24, 3404 - 3412

FBXL13 directs the proteolysis of CEP192 to regulate centrosome homeostasis and cell migration.

Fung E. et al, (2018), EMBO Rep, 19

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Galluzzi L. et al, (2018), Cell Death Differ, 25, 486 - 541

Two paths to let the replisome go.

D'Angiolella V. and Guardavaccaro D., (2017), Cell Death Differ, 24, 1140 - 1141

Ribonucleotide Reductase Requires Subunit Switching in Hypoxia to Maintain DNA Replication.

Foskolou IP. et al, (2017), Mol Cell, 66, 206 - 220.e9

SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development.

Raducu M. et al, (2016), EMBO J, 35, 1400 - 1416

WEE1 inhibition selectively kills histone H3K36me3-deficient cancers by dNTP starvation

Pfister SX. et al, (2016), CANCER RESEARCH, 76

Inhibiting WEE1 Selectively Kills Histone H3K36me3-Deficient Cancers by dNTP Starvation.

Pfister SX. et al, (2015), Cancer Cell, 28, 557 - 568

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