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Publications

Recent publications published by researchers at the MRC WIMM.

Addendum: Precise tuning of gene expression levels in mammalian cells.

Michaels YS. et al, (2019), Nat Commun, 10

Decoupling tRNA promoter and processing activities enables specific Pol-II Cas9 guide RNA expression.

Knapp DJHF. et al, (2019), Nat Commun, 10

Precise tuning of gene expression levels in mammalian cells.

Michaels YS. et al, (2019), Nat Commun, 10

CRISPR-Cas9 targeting of MMP13 in human chondrocytes leads to significantly reduced levels of the metalloproteinase and enhanced type II collagen accumulation.

Seidl CI. et al, (2019), Osteoarthritis Cartilage, 27, 140 - 147

MicroRNAs Regulate Sleep and Sleep Homeostasis in Drosophila.

Goodwin PR. et al, (2018), Cell Rep, 23, 3776 - 3786

Precise tuning of gene expression output levels in mammalian cells

Michaels Y. et al, (2018)

Decoupling tRNA promoter and processing activities enables specific Pol-II Cas9 guide RNA expression

Knapp DJHF. et al, (2018)

The Drosophila homologue of MEGF8 is essential for early development.

Lloyd DL. et al, (2018), Sci Rep, 8

Regulation of Circadian Behavior by Astroglial MicroRNAs in Drosophila.

You S. et al, (2018), Genetics, 208, 1195 - 1207

In situ functional dissection of RNA cis-regulatory elements by multiplex CRISPR-Cas9 genome engineering.

Wu Q. et al, (2017), Nat Commun, 8

A multiplexable TALE-based binary expression system for in vivo cellular interaction studies.

Toegel M. et al, (2017), Nat Commun, 8

Engineering Synthetic Signaling Pathways with Programmable dCas9-Based Chimeric Receptors.

Baeumler TA. et al, (2017), Cell Rep, 20, 2639 - 2653

Treating the placenta to prevent adverse effects of gestational hypoxia on fetal brain development.

Phillips TJ. et al, (2017), Sci Rep, 7

Identification of Usp8 as a toxicity modifying Deubiquitinase for alpha-synuclein

Alexopoulou Z. et al, (2017), EUROPEAN JOURNAL OF NEUROLOGY, 24, 766 - 766

Rational design of inducible CRISPR guide RNAs for de novo assembly of transcriptional programs.

Ferry QRV. et al, (2017), Nat Commun, 8

Interrogation of Functional miRNA-Target Interactions by CRISPR/Cas9 Genome Engineering.

Michaels YS. et al, (2017), Methods Mol Biol, 1580, 79 - 97

Deubiquitinase Usp8 regulates α-synuclein clearance and modifies its toxicity in Lewy body disease.

Alexopoulou Z. et al, (2016), Proc Natl Acad Sci U S A, 113, E4688 - E4697

Up-regulation of miR-31 in human atrial fibrillation begets the arrhythmia by depleting dystrophin and neuronal nitric oxide synthase.

Reilly SN. et al, (2016), Sci Transl Med, 8

Tiny giants of gene regulation: experimental strategies for microRNA functional studies.

Steinkraus BR. et al, (2016), Wiley Interdiscip Rev Dev Biol, 5, 311 - 362

The Drosophila tricellular junction protein Gliotactin regulates its own mRNA levels through BMP-mediated induction of miR-184.

Sharifkhodaei Z. et al, (2016), J Cell Sci, 129, 1477 - 1489

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