Recent publications published by researchers at the MRC WIMM.
Addendum: Precise tuning of gene expression levels in mammalian cells.
Journal article
Michaels YS. et al, (2019), Nat Commun, 10
Decoupling tRNA promoter and processing activities enables specific Pol-II Cas9 guide RNA expression.
Journal article
Knapp DJHF. et al, (2019), Nat Commun, 10
Precise tuning of gene expression levels in mammalian cells.
Journal article
Michaels YS. et al, (2019), Nat Commun, 10
CRISPR-Cas9 targeting of MMP13 in human chondrocytes leads to significantly reduced levels of the metalloproteinase and enhanced type II collagen accumulation.
Journal article
Seidl CI. et al, (2019), Osteoarthritis Cartilage, 27, 140 - 147
MicroRNAs Regulate Sleep and Sleep Homeostasis in Drosophila.
Journal article
Goodwin PR. et al, (2018), Cell Rep, 23, 3776 - 3786
Precise tuning of gene expression output levels in mammalian cells
Journal article
Michaels Y. et al, (2018)
Decoupling tRNA promoter and processing activities enables specific Pol-II Cas9 guide RNA expression
Journal article
Knapp DJHF. et al, (2018)
The Drosophila homologue of MEGF8 is essential for early development.
Journal article
Lloyd DL. et al, (2018), Sci Rep, 8
Regulation of Circadian Behavior by Astroglial MicroRNAs in Drosophila.
Journal article
You S. et al, (2018), Genetics, 208, 1195 - 1207
In situ functional dissection of RNA cis-regulatory elements by multiplex CRISPR-Cas9 genome engineering.
Journal article
Wu Q. et al, (2017), Nat Commun, 8
A multiplexable TALE-based binary expression system for in vivo cellular interaction studies.
Journal article
Toegel M. et al, (2017), Nat Commun, 8
Engineering Synthetic Signaling Pathways with Programmable dCas9-Based Chimeric Receptors.
Journal article
Baeumler TA. et al, (2017), Cell Rep, 20, 2639 - 2653
Treating the placenta to prevent adverse effects of gestational hypoxia on fetal brain development.
Journal article
Phillips TJ. et al, (2017), Sci Rep, 7
Identification of Usp8 as a toxicity modifying Deubiquitinase for alpha-synuclein
Conference paper
Alexopoulou Z. et al, (2017), EUROPEAN JOURNAL OF NEUROLOGY, 24, 766 - 766
Rational design of inducible CRISPR guide RNAs for de novo assembly of transcriptional programs.
Journal article
Ferry QRV. et al, (2017), Nat Commun, 8
Interrogation of Functional miRNA-Target Interactions by CRISPR/Cas9 Genome Engineering.
Journal article
Michaels YS. et al, (2017), Methods Mol Biol, 1580, 79 - 97
Deubiquitinase Usp8 regulates α-synuclein clearance and modifies its toxicity in Lewy body disease.
Journal article
Alexopoulou Z. et al, (2016), Proc Natl Acad Sci U S A, 113, E4688 - E4697
Up-regulation of miR-31 in human atrial fibrillation begets the arrhythmia by depleting dystrophin and neuronal nitric oxide synthase.
Journal article
Reilly SN. et al, (2016), Sci Transl Med, 8
Tiny giants of gene regulation: experimental strategies for microRNA functional studies.
Journal article
Steinkraus BR. et al, (2016), Wiley Interdiscip Rev Dev Biol, 5, 311 - 362
The Drosophila tricellular junction protein Gliotactin regulates its own mRNA levels through BMP-mediated induction of miR-184.
Journal article
Sharifkhodaei Z. et al, (2016), J Cell Sci, 129, 1477 - 1489