Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Publications

Recent publications published by researchers at the MRC WIMM.

The BET inhibitor CPI203 promotes ex vivo expansion of cord blood long-term repopulating HSCs and megakaryocytes.

Hua P. et al, (2020), Blood

H3K79me2/3 controls enhancer-promoter interactions and activation of the pan-cancer stem cell marker PROM1/CD133 in MLL-AF4 leukemia cells.

Godfrey L. et al, (2020), Leukemia

BET inhibition disrupts transcription but retains enhancer-promoter contact

Crump N. et al, (2019)

Discovery of a CD10-negative B-progenitor in human fetal life identifies unique ontogeny-related developmental programs.

O'Byrne S. et al, (2019), Blood, 134, 1059 - 1071

Rationale for targeting BCL6 in MLL-rearranged acute lymphoblastic leukemia.

Hurtz C. et al, (2019), Genes Dev, 33, 1265 - 1279

Why are so many MLL lysine methyltransferases required for normal mammalian development?

Crump NT. and Milne TA., (2019), Cell Mol Life Sci, 76, 2885 - 2898

DOT1L inhibition reveals a distinct subset of enhancers dependent on H3K79 methylation.

Godfrey L. et al, (2019), Nat Commun, 10

Addendum: Precise tuning of gene expression levels in mammalian cells.

Michaels YS. et al, (2019), Nat Commun, 10

Decoupling tRNA promoter and processing activities enables specific Pol-II Cas9 guide RNA expression.

Knapp DJHF. et al, (2019), Nat Commun, 10

Precise tuning of gene expression levels in mammalian cells.

Michaels YS. et al, (2019), Nat Commun, 10

DOT1L inhibition reveals a distinct class of enhancers dependent on H3K79 methylation

Godfrey L. et al, (2018)

Author Correction: Metabolic gatekeeper function of B-lymphoid transcription factors.

Chan LN. et al, (2018), Nature, 558

The basic helix-loop-helix transcription factor SHARP1 is an oncogenic driver in MLL-AF6 acute myelogenous leukemia.

Numata A. et al, (2018), Nat Commun, 9

Ezh2 and Runx1 Mutations Collaborate to Initiate Lympho-Myeloid Leukemia in Early Thymic Progenitors.

Booth CAG. et al, (2018), Cancer Cell, 33, 274 - 291.e8

LEDGF: a leukemia-specific target.

Milne TA., (2018), Blood, 131, 4 - 5

The Cks1/Cks2 axis fine-tunes Mll1 expression and is crucial for MLL-rearranged leukaemia cell viability.

Grey W. et al, (2018), Biochim Biophys Acta Mol Cell Res, 1865, 105 - 116

In situ functional dissection of RNA cis-regulatory elements by multiplex CRISPR-Cas9 genome engineering.

Wu Q. et al, (2017), Nat Commun, 8

Hepcidin is regulated by promoter-associated histone acetylation and HDAC3.

Pasricha S-R. et al, (2017), Nat Commun, 8

NEXT GENERATION SEQUENCING TECHNIQUES REVEAL MOLECULAR MECHANISMS OF MYB REGULATION AND FUNCTION IN MLL-AF9 LEUKEMIA

Lau I-J. et al, (2017), HAEMATOLOGICA, 102, 207 - 207

Mouse models of MLL leukemia: recapitulating the human disease.

Milne TA., (2017), Blood, 129, 2217 - 2223

Load More

Include forthcoming?