Recent publications published by researchers at the MRC WIMM.
PROM1/CD133 MARKS A PROLIFERATIVE STEM CELL LIKE POPULATION OF BLASTS IN KMT2A REARRANGED INFANT ALL.
Cross JW. et al, (2025), Blood Adv
Iron deficiency causes aspartate-sensitive dysfunction in CD8+ T cells.
Teh MR. et al, (2025), Nat Commun, 16
Engineering antisense oligonucleotides for targeted mRNA degradation through lysosomal trafficking.
Kashyap D. et al, (2025), Chem Sci
Is Enhancer Function Driven by Protein-Protein Interactions? From Bacteria to Leukemia.
Crump NT. and Milne TA., (2025), Bioessays
Active regulatory elements recruit cohesin to establish cell specific chromatin domains.
Georgiades E. et al, (2025), Sci Rep, 15
DYRK1A inhibition results in MYC and ERK activation rendering KMT2A-R acute lymphoblastic leukemia cells sensitive to BCL2 inhibition.
Ayyadevara VSSA. et al, (2025), Leukemia
NG2 is a target gene of MLL-AF4 and underlies glucocorticoid resistance in MLL-r B-ALL by regulating NR3C1 expression.
Lopez-Millan B. et al, (2024), Blood
Lead optimisation of OXS007417: in vivo PK profile and hERG liability modulation to optimise a small molecule differentiation agent for the potential treatment of acute myeloid leukaemia.
Cogswell TJ. et al, (2024), RSC Med Chem, 15, 3495 - 3506
Chromatin and aberrant enhancer activity in KMT2A rearranged acute lymphoblastic leukemia.
Milne TA., (2024), Curr Opin Genet Dev, 86
Effects of glycation end-products on the dental pulp in patients with type 2 diabetes.
Alsamahi S. et al, (2023), Int Endod J, 56, 1373 - 1384
Mutate and Conjugate: A Method to Enable Rapid In-Cell Target Validation.
Thomas AM. et al, (2023), ACS Chem Biol
Disrupted propionate metabolism evokes transcriptional changes in the heart by increasing histone acetylation and propionylation
Park KC. et al, (2023), Nature Cardiovascular Research
Phenotypic screening identifies a trisubstituted imidazo[1,2-a]pyridine series that induces differentiation in multiple AML cell lines.
Josa-Culleré L. et al, (2023), Eur J Med Chem, 258