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Publications

Recent publications published by researchers at the MRC WIMM.

Is Enhancer Function Driven by Protein-Protein Interactions? From Bacteria to Leukemia.

Crump NT. and Milne TA., (2025), Bioessays

DYRK1A inhibition results in MYC and ERK activation rendering KMT2A-R acute lymphoblastic leukemia cells sensitive to BCL2 inhibition.

Ayyadevara VSSA. et al, (2025), Leukemia

Going nuclear: Improved antisense oligonucleotide activity through conjugation with a nuclear importer

Kashyap D. et al, (2025)

Bi-specific CAR-iNKT cell immunotherapy for high-risk KMT2A-rearranged leukemia outperforms CAR-T in an NKG2D-dependent manner and eradicates leptomeningeal disease

Ren H. et al, (2025)

Going nuclear: Improved antisense oligonucleotide activity through conjugation with a nuclear importer

Kashyap D. et al, (2024)

NG2 is a target gene of MLL-AF4 and underlies glucocorticoid resistance in MLL-r B-ALL by regulating NR3C1 expression.

Lopez-Millan B. et al, (2024), Blood

Lead optimisation of OXS007417: in vivo PK profile and hERG liability modulation to optimise a small molecule differentiation agent for the potential treatment of acute myeloid leukaemia.

Cogswell TJ. et al, (2024), RSC Med Chem, 15, 3495 - 3506

Chromatin and aberrant enhancer activity in KMT2A rearranged acute lymphoblastic leukemia.

Milne TA., (2024), Curr Opin Genet Dev, 86

Iron deficiency causes aspartate-sensitive metabolic and proliferative dysfunction in CD8+ T cells

Teh MR. et al, (2024)

HDAC inhibitor derivatives induce differentiation of leukemic cells through two distinct and separable mechanisms

Kumar P. et al, (2024)

Effects of glycation end-products on the dental pulp in patients with type 2 diabetes.

Alsamahi S. et al, (2023), Int Endod J, 56, 1373 - 1384

Mutate and Conjugate: A Method to Enable Rapid In-Cell Target Validation.

Thomas AM. et al, (2023), ACS Chem Biol

Disrupted propionate metabolism evokes transcriptional changes in the heart by increasing histone acetylation and propionylation

Park KC. et al, (2023), Nature Cardiovascular Research

Phenotypic screening identifies a trisubstituted imidazo[1,2-a]pyridine series that induces differentiation in multiple AML cell lines.

Josa-Culleré L. et al, (2023), Eur J Med Chem, 258

A human genome editing-based MLL::AF4 B-cell ALL model recapitulates key cellular and molecular leukemogenic features.

Bueno C. et al, (2023), Blood

Modelling acquired resistance to DOT1L inhibition exhibits the adaptive potential of KMT2A-rearranged acute lymphoblastic leukemia.

Schneider P. et al, (2023), Exp Hematol Oncol, 12

MLL-AF4 cooperates with PAF1 and FACT to drive high-density enhancer interactions in leukemia.

Crump NT. et al, (2023), Nat Commun, 14

Author Correction: Capture-C: a modular and flexible approach for high-resolution chromosome conformation capture.

Downes DJ. et al, (2023), Nat Protoc

Active regulatory elements recruit cohesin to establish cell-specific chromatin domains

Georgiades E. et al, (2023)

Dysregulation of chromatin via H3K27 methylation underpins differentiation arrest in Isocitrate dehydrogenase-mutant Acute Myeloid Leukaemia

Silveira DRA. et al, (2023)

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