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Publications

Recent publications published by researchers at the MRC WIMM.

Chromatin accessibility governs the differential response of cancer and T cells to arginine starvation.

Crump NT. et al, (2021), Cell Rep, 35

BET inhibition disrupts transcription but retains enhancer-promoter contact.

Crump NT. et al, (2021), Nat Commun, 12

H3K79me2/3 controls enhancer-promoter interactions and activation of the pan-cancer stem cell marker PROM1/CD133 in MLL-AF4 leukemia cells.

Godfrey L. et al, (2021), Leukemia, 35, 90 - 106

The BET inhibitor CPI203 promotes ex vivo expansion of cord blood long-term repopulating HSCs and megakaryocytes.

Hua P. et al, (2020), Blood, 136, 2410 - 2415

A novel human fetal liver-derived model reveals that MLL-AF4 drives a distinct fetal gene expression program in infant ALL

Rice S. et al, (2020), bioRxiv

The MLL family of proteins in normal development and disease.

Milne TA., (2020), Biochim Biophys Acta Gene Regul Mech, 1863

Phenotypic analysis of an MLL-AF4 gene regulatory network reveals indirect CASP9 repression as a mode of inducing apoptosis resistance

Harman JR. et al, (2020)

BET inhibition disrupts transcription but retains enhancer-promoter contact

Crump N. et al, (2019)

Rationale for Targeting BCL6 in MLL-Rearranged B-ALL

Chan LN. et al, (2019), BLOOD, 134

Discovery of a CD10-negative B-progenitor in human fetal life identifies unique ontogeny-related developmental programs.

O'Byrne S. et al, (2019), Blood, 134, 1059 - 1071

Rationale for targeting BCL6 in MLL-rearranged acute lymphoblastic leukemia.

Hurtz C. et al, (2019), Genes Dev, 33, 1265 - 1279

Why are so many MLL lysine methyltransferases required for normal mammalian development?

Crump NT. and Milne TA., (2019), Cell Mol Life Sci, 76, 2885 - 2898

DOT1L inhibition reveals a distinct subset of enhancers dependent on H3K79 methylation.

Godfrey L. et al, (2019), Nat Commun, 10

Addendum: Precise tuning of gene expression levels in mammalian cells.

Michaels YS. et al, (2019), Nat Commun, 10

Decoupling tRNA promoter and processing activities enables specific Pol-II Cas9 guide RNA expression.

Knapp DJHF. et al, (2019), Nat Commun, 10

Precise tuning of gene expression levels in mammalian cells.

Michaels YS. et al, (2019), Nat Commun, 10

DOT1L inhibition reveals a distinct class of enhancers dependent on H3K79 methylation

Godfrey L. et al, (2018)

Author Correction: Metabolic gatekeeper function of B-lymphoid transcription factors.

Chan LN. et al, (2018), Nature, 558

The basic helix-loop-helix transcription factor SHARP1 is an oncogenic driver in MLL-AF6 acute myelogenous leukemia.

Numata A. et al, (2018), Nat Commun, 9

Ezh2 and Runx1 Mutations Collaborate to Initiate Lympho-Myeloid Leukemia in Early Thymic Progenitors.

Booth CAG. et al, (2018), Cancer Cell, 33, 274 - 291.e8

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