Recent publications published by researchers at the MRC WIMM.
Is Enhancer Function Driven by Protein-Protein Interactions? From Bacteria to Leukemia.
Crump NT. and Milne TA., (2025), Bioessays
Active regulatory elements recruit cohesin to establish cell specific chromatin domains.
Georgiades E. et al, (2025), Sci Rep, 15
DYRK1A inhibition results in MYC and ERK activation rendering KMT2A-R acute lymphoblastic leukemia cells sensitive to BCL2 inhibition.
Ayyadevara VSSA. et al, (2025), Leukemia
NG2 is a target gene of MLL-AF4 and underlies glucocorticoid resistance in MLL-r B-ALL by regulating NR3C1 expression.
Lopez-Millan B. et al, (2024), Blood
Lead optimisation of OXS007417: in vivo PK profile and hERG liability modulation to optimise a small molecule differentiation agent for the potential treatment of acute myeloid leukaemia.
Cogswell TJ. et al, (2024), RSC Med Chem, 15, 3495 - 3506
Chromatin and aberrant enhancer activity in KMT2A rearranged acute lymphoblastic leukemia.
Milne TA., (2024), Curr Opin Genet Dev, 86
Effects of glycation end-products on the dental pulp in patients with type 2 diabetes.
Alsamahi S. et al, (2023), Int Endod J, 56, 1373 - 1384
Mutate and Conjugate: A Method to Enable Rapid In-Cell Target Validation.
Thomas AM. et al, (2023), ACS Chem Biol
Disrupted propionate metabolism evokes transcriptional changes in the heart by increasing histone acetylation and propionylation
Park KC. et al, (2023), Nature Cardiovascular Research
Phenotypic screening identifies a trisubstituted imidazo[1,2-a]pyridine series that induces differentiation in multiple AML cell lines.
Josa-Culleré L. et al, (2023), Eur J Med Chem, 258
Modelling acquired resistance to DOT1L inhibition exhibits the adaptive potential of KMT2A-rearranged acute lymphoblastic leukemia.
Schneider P. et al, (2023), Exp Hematol Oncol, 12
MLL-AF4 cooperates with PAF1 and FACT to drive high-density enhancer interactions in leukemia.
Crump NT. et al, (2023), Nat Commun, 14
Author Correction: Capture-C: a modular and flexible approach for high-resolution chromosome conformation capture.
Downes DJ. et al, (2023), Nat Protoc