Recent publications published by researchers at the MRC WIMM.
Correction to "DNA-Programmable Protein Degradation: Dynamic Control of Proteolysis-Targeting Chimera Activity via DNA Hybridization and Strand Displacement".
Kashyap D. et al, (2026), JACS Au, 6, 653 - 655
Menin maintains enhancer-promoter interactions in a leukemia-specific manner
Sharlandjieva V. et al, (2026)
Off-the-shelf dual CAR-iNKT cell immunotherapy eradicates medullary and leptomeningeal high-risk KMT2A-rearranged leukemia.
Ren H. et al, (2026), Blood, 147, 180 - 196
A genome-wide screen identifies Runx2 as a novel regulator of hematopoietic stem cell expansion and T-cell commitment.
Meaker GA. et al, (2025), Blood, 146, 3188 - 3200
Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions.
Li H. et al, (2025), Cell, 188, 7175 - 7193.e19
Small proteins with a big job: An EMBOW-derived microprotein targets WDR5-MLL1 and suppresses transcription in leukemia.
Baillie HL. and Milne TA., (2025), Cell Chem Biol, 32, 1305 - 1307
Enhancer heterogeneity in acute lymphoblastic leukemia drives differential gene expression in patients.
Smith AL. et al, (2025), Blood, 146, 2073 - 2087
PROM1/CD133 marks a proliferative stem cell-like population of blasts in KMT2A rearranged infant ALL.
Cross JW. et al, (2025), Blood Adv, 9, 4607 - 4613
DNA-Programmable Protein Degradation: Dynamic Control of Proteolysis-Targeting Chimera Activity via DNA Hybridization and Strand Displacement.
Kashyap D. et al, (2025), JACS Au, 5, 3799 - 3807
Harnessing BET-Bromodomain Assisted Nuclear Import for Targeted Subcellular Localization and Enhanced Efficacy of Antisense Oligonucleotides.
Kashyap D. et al, (2025), J Am Chem Soc, 147, 29478 - 29488
Engineering antisense oligonucleotides for targeted mRNA degradation through lysosomal trafficking.
Kashyap D. et al, (2025), Chem Sci, 16, 13096 - 13105
Iron deficiency causes aspartate-sensitive dysfunction in CD8+ T cells.
Teh MR. et al, (2025), Nat Commun, 16
Is Enhancer Function Driven by Protein-Protein Interactions? From Bacteria to Leukemia.
Crump NT. and Milne TA., (2025), Bioessays, 47
DYRK1A inhibition results in MYC and ERK activation rendering KMT2A-R acute lymphoblastic leukemia cells sensitive to BCL2 inhibition.
Ayyadevara VSSA. et al, (2025), Leukemia, 39, 1078 - 1089
Active regulatory elements recruit cohesin to establish cell specific chromatin domains.
Georgiades E. et al, (2025), Sci Rep, 15
Context-dependent recruitment of co-factors directs RUNX1 activity in normal and leukemic cells
Dimou D. et al, (2025), BLOOD, 146