Recent publications published by researchers at the MRC WIMM.
Long-persisting SARS-CoV-2 spike-specific CD4+ T cells associated with mild disease and increased cytotoxicity post COVID-19.
Liu G. et al, (2025), Nat Commun, 16
Tumor-specific CD8 T cell characterization in HR+ breast cancer reveals an impaired antitumoral response in patients with lymph node metastasis.
Pinho MP. et al, (2025), Cell Rep Med, 6
Pleural fluid proteomics from patients with pleural infection shows signatures of diverse neutrophilic responses: The Oxford Pleural Infection Endotyping Study (TORPIDS-2).
Kanellakis NI. et al, (2025), Eur Respir J, 66
Immunogenicity of MVA-BN vaccine deployed as mpox prophylaxis: a prospective, single-centre, cohort study and analysis of transcriptomic predictors of response.
Drennan PG. et al, (2025), Lancet Microbe, 6
T cell memory response to MPXV infection exhibits greater effector function and migratory potential compared to MVA-BN vaccination.
Chen J-L. et al, (2025), Nat Commun, 16
Impact of COVID-19 pandemic on rates of congenital heart disease procedures among children: prospective cohort analyses of 26 270 procedures in 17 860 children using CVD-COVID-UK consortium record linkage data.
Karthikeyan Suseeladevi A. et al, (2025), Open Heart, 12
Long term health outcomes in people with diabetes 12 months after hospitalisation with COVID-19 in the UK: a prospective cohort study.
Gharibzadeh S. et al, (2025), EClinicalMedicine, 79
Proximity proteomics reveals UCH-L1 as an essential regulator of NLRP3-mediated IL-1β production in human macrophages and microglia.
Liang Z. et al, (2024), Cell Rep, 43
Transient synaptic CD61 pairing with CD103 increases the cytotoxicity of antigen-specific T cells.
(2024), Nat Immunol, 25, 739 - 740
Unconventional human CD61 pairing with CD103 promotes TCR signaling and antigen-specific T cell cytotoxicity.
Hamid MHBA. et al, (2024), Nat Immunol, 25, 834 - 846
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease.
Liew F. et al, (2024), Nat Immunol, 25, 607 - 621
Accelarated immune ageing is associated with COVID-19 disease severity.
Lord JM. et al, (2024), Immun Ageing, 21
Durability and cross-reactive immune memory to SARS-CoV-2 in individuals 2 years after recovery from COVID-19: a longitudinal cohort study.
Guo L. et al, (2024), Lancet Microbe, 5, e24 - e33
Omicron BA.1 breakthrough infections in inactivated COVID-19 vaccine recipients induced distinct pattern of antibody and T cell responses to different Omicron sublineages.
Guo L. et al, (2023), Emerg Microbes Infect, 12
Probing long COVID through a proteomic lens: a comprehensive two-year longitudinal cohort study of hospitalised survivors.
Gu X. et al, (2023), EBioMedicine, 98
Single cell spatial analysis reveals inflammatory foci of immature neutrophil and CD8 T cells in COVID-19 lungs.
Weeratunga P. et al, (2023), Nat Commun, 14
Engineering immunosuppressive drug-resistant armored (IDRA) SARS-CoV-2 T cells for cell therapy.
Chen Q. et al, (2023), Cell Mol Immunol, 20, 1300 - 1312