Recent publications published by researchers at the MRC WIMM.
Selective advantage of mutant stem cells in human clonal hematopoiesis is associated with attenuated response to inflammation and aging.
Journal article
Jakobsen NA. et al, (2024), Cell Stem Cell, 31, 1127 - 1144.e17
Splicing factor YBX1 mediates persistence of JAK2-mutated neoplasms
Journal article
Jayavelu AK. et al, (2020), Nature, 588, 157 - 163
Enhanced differentiation of functional human T cells in NSGW41 mice with tissue-specific expression of human interleukin-7
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Coppin E. et al, (2020)
Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition).
Journal article
Cossarizza A. et al, (2019), Eur J Immunol, 49, 1457 - 1973
Comparative RNAi Screens in Isogenic Human Stem Cells Reveal SMARCA4 as a Differential Regulator
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Güneş C. et al, (2019), Stem Cell Reports, 12, 1084 - 1098
Epigenetic aging of human hematopoietic cells is not accelerated upon transplantation into mice
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Frobel J. et al, (2018), Clinical Epigenetics, 10
Improved Human Erythropoiesis and Platelet Formation in Humanized NSGW41 Mice
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Rahmig S. et al, (2016), Stem Cell Reports, 7, 591 - 601
Multilineage readout after HSC expansion – erythrocytes matter
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Mende N. et al, (2016), Cell Cycle, 15, 1032 - 1033
GSK3 Deficiencies in Hematopoietic Stem Cells Initiate Pre-neoplastic State that Is Predictive of Clinical Outcomes of Human Acute Leukemia
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Guezguez B. et al, (2016), Cancer Cell, 29, 61 - 74
Humanized Mouse Models for Type 1 Diabetes Including Pancreatic Islet Transplantation
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Rahmig S. et al, (2014), Hormone and Metabolic Research, 47, 43 - 47
Kit regulates HSC engraftment across the human-mouse species barrier.
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Cosgun KN. et al, (2014), Cell Stem Cell, 15, 227 - 238
Improved HSC reconstitution and protection from inflammatory stress and chemotherapy in mice lacking granzyme B
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Carnevalli LS. et al, (2014), Journal of Experimental Medicine, 211, 769 - 779