Recent publications published by researchers at the MRC WIMM.
Mitotic DNA synthesis is caused by transcription-replication conflicts in BRCA2-deficient cells.
Journal article
Groelly FJ. et al, (2022), Mol Cell, 82, 3382 - 3397.e7
Mechanism of Bloom syndrome complex assembly required for double Holliday junction dissolution and genome stability.
Journal article
Hodson C. et al, (2022), Proc Natl Acad Sci U S A, 119
The Bloom syndrome complex senses RPA-coated single-stranded DNA to restart stalled replication forks.
Journal article
Shorrocks A-MK. et al, (2021), Nat Commun, 12
MDC1 Interacts with TOPBP1 to Maintain Chromosomal Stability during Mitosis.
Journal article
Leimbacher P-A. et al, (2019), Mol Cell, 74, 571 - 583.e8
Chemosensitivity profiling of osteosarcoma tumour cell lines identifies a model of BRCAness.
Journal article
Holme H. et al, (2018), Sci Rep, 8
ATR Is a Therapeutic Target in Synovial Sarcoma.
Journal article
Jones SE. et al, (2017), Cancer Res, 77, 7014 - 7026
ATR inhibitors as a synthetic lethal therapy for tumours deficient in ARID1A.
Journal article
Williamson CT. et al, (2016), Nat Commun, 7